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Ccny cyclin Y [ Mus musculus (house mouse) ]

Gene ID: 67974, updated on 9-Dec-2024

Summary

Official Symbol
Ccnyprovided by MGI
Official Full Name
cyclin Yprovided by MGI
Primary source
MGI:MGI:1915224
See related
Ensembl:ENSMUSG00000024286 AllianceGenome:MGI:1915224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of canonical Wnt signaling pathway. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including cerebral cortex; genitourinary system; gut; mammary gland; and spleen. Orthologous to human CCNY (cyclin Y). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 25.9), ovary adult (RPKM 20.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ccny in Genome Data Viewer
Location:
18 A1; 18 4.91 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9312304..9450188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9312304..9450154, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1632 Neighboring gene frizzled class receptor 8 Neighboring gene STARR-seq mESC enhancer starr_43772 Neighboring gene STARR-seq mESC enhancer starr_43773 Neighboring gene STARR-seq mESC enhancer starr_43774 Neighboring gene gap junction protein, delta 4 Neighboring gene STARR-positive B cell enhancer ABC_E7573 Neighboring gene STARR-seq mESC enhancer starr_43776 Neighboring gene predicted gene, 35458 Neighboring gene family with sequence similarity 76, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cyclin-Y
Names
cyclin fold protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026484.4NP_080760.2  cyclin-Y

    See identical proteins and their annotated locations for NP_080760.2

    Status: VALIDATED

    Source sequence(s)
    AC108777, AK014201, AK014507, AK028696, AW048376
    Consensus CDS
    CCDS29050.1
    UniProtKB/Swiss-Prot
    Q8BGU5, Q8CI87, Q9CYN5
    Related
    ENSMUSP00000050001.5, ENSMUST00000053917.6
    Conserved Domains (1) summary
    cd20540
    Location:166262
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    9312304..9450188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250583.2XP_030106443.1  cyclin-Y isoform X2

    Conserved Domains (1) summary
    pfam00134
    Location:101223
    Cyclin_N; Cyclin, N-terminal domain
  2. XM_030250584.2XP_030106444.1  cyclin-Y isoform X4

    Conserved Domains (1) summary
    cd20540
    Location:27123
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
  3. XM_036161266.1XP_036017159.1  cyclin-Y isoform X4

    Conserved Domains (1) summary
    cd20540
    Location:27123
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
  4. XM_030250582.1XP_030106442.1  cyclin-Y isoform X1

    Conserved Domains (1) summary
    pfam00134
    Location:89211
    Cyclin_N; Cyclin, N-terminal domain
  5. XM_036161265.1XP_036017158.1  cyclin-Y isoform X3

    Conserved Domains (1) summary
    cl40454
    Location:166193
    CYCLIN_SF; Cyclin box fold superfamily