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Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 [ Mus musculus (house mouse) ]

Gene ID: 67972, updated on 22-Aug-2021

Summary

Official Symbol
Atp2b1provided by MGI
Official Full Name
ATPase, Ca++ transporting, plasma membrane 1provided by MGI
Primary source
MGI:MGI:104653
See related
Ensembl:ENSMUSG00000019943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PMC; Pmca1; 2810442I22Rik; E130111D10Rik
Expression
Broad expression in frontal lobe adult (RPKM 30.2), cortex adult (RPKM 27.6) and 21 other tissues See more
Orthologs
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Genomic context

See Atp2b1 in Genome Data Viewer
Location:
10; 10 C3
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98750243..98862005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (98914630..99026143)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (98377786..98488777)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40750 Neighboring gene predicted gene, 34346 Neighboring gene predicted gene, 53607 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene POC1 centriolar protein B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion export ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasma membrane calcium-transporting ATPase 1
Names
plasma membrane calcium ATPase
plasma membrane calcium pump
NP_001346435.1
NP_001346436.1
NP_001346437.1
NP_001346438.1
NP_080758.1
XP_011241850.1
XP_011241851.1
XP_030101104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359506.1NP_001346435.1  plasma membrane calcium-transporting ATPase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ128577, CJ321142, CK393435, CK624413, CN691756, CV559947
    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031178
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  2. NM_001359507.1NP_001346436.1  plasma membrane calcium-transporting ATPase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ321142, CK393435, CK624413, CN691756, CV559947
    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  3. NM_001359508.1NP_001346437.1  plasma membrane calcium-transporting ATPase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ128577, CJ321142, CK393435, CK624413, CN691756, CV559947
    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  4. NM_001359509.1NP_001346438.1  plasma membrane calcium-transporting ATPase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ128577, CJ321142, CK393435, CK624413, CN691756, CV559947
    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  5. NM_026482.2NP_080758.1  plasma membrane calcium-transporting ATPase 1 isoform 2

    See identical proteins and their annotated locations for NP_080758.1

    Status: VALIDATED

    Source sequence(s)
    AC153906, AC160410, AI892140, AK133920, BC030901, CJ321142
    Consensus CDS
    CCDS24145.1
    UniProtKB/Swiss-Prot
    G5E829
    Related
    ENSMUSP00000020107.8, ENSMUST00000020107.8
    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031149
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    98750243..98862005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243549.4XP_011241851.1  plasma membrane calcium-transporting ATPase 1 isoform X2

    See identical proteins and their annotated locations for XP_011241851.1

    UniProtKB/Swiss-Prot
    G5E829
    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031149
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  2. XM_011243548.4XP_011241850.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011241850.1

    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031178
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  3. XM_030245244.1XP_030101104.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    Conserved Domains (2) summary
    TIGR01517
    Location:151064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11031178
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
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