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U2surp U2 snRNP-associated SURP domain containing [ Mus musculus (house mouse) ]

Gene ID: 67958, updated on 30-Apr-2024

Summary

Official Symbol
U2surpprovided by MGI
Official Full Name
U2 snRNP-associated SURP domain containingprovided by MGI
Primary source
MGI:MGI:1915208
See related
Ensembl:ENSMUSG00000032407 AllianceGenome:MGI:1915208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sr140; 2610101N10Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Part of U2 snRNP. Is expressed in central nervous system and sensory organ. Orthologous to human U2SURP (U2 snRNP associated SURP domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 12.0), CNS E14 (RPKM 8.4) and 19 other tissues See more
Orthologs
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Genomic context

See U2surp in Genome Data Viewer
Location:
9 E3.3; 9 50.11 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95338947..95394049, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95456894..95511996, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:95326297-95326598 Neighboring gene FCF1 small subunit processome component homolog pseudogene Neighboring gene predicted gene, 32133 Neighboring gene STARR-positive B cell enhancer ABC_E6789 Neighboring gene STARR-seq mESC enhancer starr_24932 Neighboring gene STARR-seq mESC enhancer starr_24934 Neighboring gene progestin and adipoQ receptor family member IX Neighboring gene predicted gene, 32542

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
U2 snRNP-associated SURP motif-containing protein
Names
140 kDa Ser/Arg-rich domain protein
U2-associated protein SR140

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114977.1NP_001108449.1  U2 snRNP-associated SURP motif-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001108449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC159895
    Consensus CDS
    CCDS52889.1
    UniProtKB/Swiss-Prot
    E9QK93, Q6NV83, Q9CSW7, Q9CT00
    Related
    ENSMUSP00000078602.6, ENSMUST00000079659.12
    Conserved Domains (5) summary
    smart00582
    Location:541676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156352
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:273356
    RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
    cd21370
    Location:836884
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:429480
    Surp; Surp module
  2. NM_001357974.1NP_001344903.1  U2 snRNP-associated SURP motif-containing protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159895
    Consensus CDS
    CCDS90640.1
    Related
    ENSMUSP00000151121.2, ENSMUST00000217176.2
    Conserved Domains (5) summary
    smart00582
    Location:540675
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156351
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:272355
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:429479
    Surp; Surp module
    pfam08312
    Location:842883
    cwf21; cwf21 domain
  3. NM_001357975.1NP_001344904.1  U2 snRNP-associated SURP motif-containing protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159895
    Conserved Domains (5) summary
    smart00582
    Location:496631
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:112307
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:228311
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:385435
    Surp; Surp module
    pfam08312
    Location:798839
    cwf21; cwf21 domain
  4. NM_001357976.1NP_001344905.1  U2 snRNP-associated SURP motif-containing protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 5.
    Source sequence(s)
    AC159895
    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:434475
    cwf21; cwf21 domain
  5. NM_001357977.1NP_001344906.1  U2 snRNP-associated SURP motif-containing protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform 5.
    Source sequence(s)
    AC159895
    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:434475
    cwf21; cwf21 domain
  6. NM_026476.2NP_080752.2  U2 snRNP-associated SURP motif-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC159895
    Consensus CDS
    CCDS40727.1
    UniProtKB/Swiss-Prot
    Q6NV83
    Related
    ENSMUSP00000077482.7, ENSMUST00000078374.13
    Conserved Domains (4) summary
    smart00582
    Location:497632
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    cd12223
    Location:229312
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:386436
    Surp; Surp module
    pfam08312
    Location:799840
    cwf21; cwf21 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    95338947..95394049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244532.2XP_030100392.1  U2 snRNP-associated SURP motif-containing protein isoform X1

    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:434475
    cwf21; cwf21 domain
  2. XM_030244531.1XP_030100391.1  U2 snRNP-associated SURP motif-containing protein isoform X1

    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:434475
    cwf21; cwf21 domain