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Kmt5a lysine methyltransferase 5A [ Mus musculus (house mouse) ]

Gene ID: 67956, updated on 8-Dec-2022

Summary

Official Symbol
Kmt5aprovided by MGI
Official Full Name
lysine methyltransferase 5Aprovided by MGI
Primary source
MGI:MGI:1915206
See related
Ensembl:ENSMUSG00000049327 AllianceGenome:MGI:1915206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Setd8; PR-SET7; PR/SET07; 2410195B05Rik
Summary
Predicted to enable histone-lysine N-methyltransferase activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to act upstream of or within cell division; chromatin organization; and methylation. Predicted to be located in cytosol and nucleoplasm. Is expressed in embryo. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 32.5), heart adult (RPKM 26.1) and 28 other tissues See more
Orthologs
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Genomic context

See Kmt5a in Genome Data Viewer
Location:
5; 5 F
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124577993..124600374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124439930..124462311)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CDK2 (cyclin-dependent kinase 2)-associated protein 1 Neighboring gene strawberry notch 1 Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene peptidylprolyl isomerase A pseudogene Neighboring gene small nuclear ribonucleoprotein 35 (U11/U12) Neighboring gene predicted gene, 52789

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117832

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H4K20 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone H4K20 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K20 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in polytene chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
N-lysine methyltransferase KMT5A
Names
H4-K20-HMTase KMT5A
H4-K20-HMTase SETD8
N-lysine methyltransferase SETD8
PR/SET domain-containing protein 07
SET domain containing (lysine methyltransferase) 8
SET domain-containing protein 8
histone-lysine N-methyltransferase KMT5A
histone-lysine N-methyltransferase SETD8
lysine-specific methylase 5A
NP_001297652.1
NP_001297654.1
NP_001297656.1
NP_084517.2
XP_006530513.1
XP_030110637.1
XP_036021341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310723.2NP_001297652.1  N-lysine methyltransferase KMT5A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127339
    Consensus CDS
    CCDS80410.1
    UniProtKB/Swiss-Prot
    Q2YDW7
    UniProtKB/TrEMBL
    D3YXI6, Q8C1L9
    Related
    ENSMUSP00000098275.3, ENSMUST00000100709.7
    Conserved Domains (1) summary
    smart00317
    Location:236353
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  2. NM_001310725.2NP_001297654.1  N-lysine methyltransferase KMT5A isoform 3

    See identical proteins and their annotated locations for NP_001297654.1

    Status: VALIDATED

    Source sequence(s)
    AC127339
    Consensus CDS
    CCDS80411.1
    UniProtKB/TrEMBL
    A0A0G2JFK5
    Related
    ENSMUSP00000143207.2, ENSMUST00000198451.2
    Conserved Domains (2) summary
    PLN02543
    Location:70164
    PLN02543; pfkB-type carbohydrate kinase family protein
    cd10528
    Location:143282
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
  3. NM_001310727.2NP_001297656.1  N-lysine methyltransferase KMT5A isoform 3

    See identical proteins and their annotated locations for NP_001297656.1

    Status: VALIDATED

    Source sequence(s)
    AC127339
    Consensus CDS
    CCDS80411.1
    UniProtKB/Swiss-Prot
    Q2YDW7
    UniProtKB/TrEMBL
    A0A0G2JFK5
    Conserved Domains (2) summary
    PLN02543
    Location:70164
    PLN02543; pfkB-type carbohydrate kinase family protein
    cd10528
    Location:143282
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
  4. NM_001405388.1NP_001392317.1  N-lysine methyltransferase KMT5A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127339
    UniProtKB/TrEMBL
    A0A0G2JFK5
  5. NM_001405390.1NP_001392319.1  N-lysine methyltransferase KMT5A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127339
  6. NM_030241.4NP_084517.2  N-lysine methyltransferase KMT5A isoform 1.

    Status: VALIDATED

    Source sequence(s)
    AC127339
    Consensus CDS
    CCDS19675.1
    UniProtKB/Swiss-Prot
    Q2YDW7
    UniProtKB/TrEMBL
    E9QNB8
    Related
    ENSMUSP00000052953.5, ENSMUST00000059580.11
    Conserved Domains (1) summary
    smart00317
    Location:222339
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124577993..124600374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165448.1XP_036021341.1  N-lysine methyltransferase KMT5A isoform X1

  2. XM_030254777.2XP_030110637.1  N-lysine methyltransferase KMT5A isoform X2

    Conserved Domains (2) summary
    PLN02543
    Location:119213
    PLN02543; pfkB-type carbohydrate kinase family protein
    cd10528
    Location:192331
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
  3. XM_006530450.5XP_006530513.1  N-lysine methyltransferase KMT5A isoform X3

    UniProtKB/TrEMBL
    A0A0G2JFK5
    Conserved Domains (2) summary
    PLN02543
    Location:70164
    PLN02543; pfkB-type carbohydrate kinase family protein
    cd10528
    Location:143282
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins