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Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 67955, updated on 9-Mar-2023

Summary

Official Symbol
Sugt1provided by MGI
Official Full Name
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1915205
See related
Ensembl:ENSMUSG00000022024 AllianceGenome:MGI:1915205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGT1; 2410174K12Rik
Summary
Predicted to be involved in protein stabilization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; eye; nervous system; reproductive system; and respiratory system. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.7), placenta adult (RPKM 20.6) and 27 other tissues See more
Orthologs
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Genomic context

See Sugt1 in Genome Data Viewer
Location:
14; 14 D3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79825100..79868237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79587660..79630797)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon TTC) Neighboring gene claspin homolog pseudogene Neighboring gene E74 like ETS transcription factor 1 Neighboring gene chondromodulin Neighboring gene predicted gene, 41218

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
protein SGT1 homolog
Names
suppressor of G2 allele of SKP1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026474.6NP_080750.1  protein SGT1 homolog

    See identical proteins and their annotated locations for NP_080750.1

    Status: VALIDATED

    Source sequence(s)
    AC129216, AK082328, AK141416
    Consensus CDS
    CCDS36988.1
    UniProtKB/Swiss-Prot
    Q9CX34, Q9D8M6
    Related
    ENSMUSP00000052942.9, ENSMUST00000054908.10
    Conserved Domains (6) summary
    cd06489
    Location:146229
    p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
    smart00028
    Location:4578
    TPR; Tetratricopeptide repeats
    PLN03088
    Location:21336
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:4474
    TPR; TPR repeat [structural motif]
    cl22853
    Location:38107
    Motor_domain; Myosin and Kinesin motor domain
    pfam05002
    Location:256336
    SGS; SGS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79825100..79868237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)