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Spata6 spermatogenesis associated 6 [ Mus musculus (house mouse) ]

Gene ID: 67946, updated on 26-Sep-2022

Summary

Official Symbol
Spata6provided by MGI
Official Full Name
spermatogenesis associated 6provided by MGI
Primary source
MGI:MGI:1915196
See related
Ensembl:ENSMUSG00000034401 AllianceGenome:MGI:1915196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRP; Hash; Mash; 1700062C23Rik
Summary
Enables myosin light chain binding activity. Involved in motile cilium assembly and spermatogenesis. Located in sperm connecting piece. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and liver and biliary system. Orthologous to human SPATA6 (spermatogenesis associated 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 127.0) and bladder adult (RPKM 5.9) See more
Orthologs
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Genomic context

See Spata6 in Genome Data Viewer
Location:
4; 4 D1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111577151..111686339)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (111719951..111829142)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 4 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene BEN domain containing 5 Neighboring gene predicted gene, 33192 Neighboring gene predicted gene 12961 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 9 Neighboring gene selection and upkeep of intraepithelial T cells 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables myosin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables myosin light chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm connecting piece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm connecting piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
spermatogenesis-associated protein 6
Names
kinesin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357231.1NP_001344160.1  spermatogenesis-associated protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK005819, AK051574, AK153098, CK622811
    UniProtKB/TrEMBL
    A0A6P7QZQ7
    Related
    ENSMUST00000143879.8
  2. NM_026470.3NP_080746.3  spermatogenesis-associated protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080746.3

    Status: VALIDATED

    Source sequence(s)
    AK005819, AK051574, AK153098, CK129415
    Consensus CDS
    CCDS38836.1
    UniProtKB/Swiss-Prot
    Q3U6K5, Q9DAI3
    Related
    ENSMUSP00000036964.8, ENSMUST00000038868.14
    Conserved Domains (1) summary
    pfam14909
    Location:11149
    SPATA6; Spermatogenesis-assoc protein 6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    111577151..111686339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164380.1XP_036020273.1  spermatogenesis-associated protein 6 isoform X2

    Conserved Domains (1) summary
    pfam14909
    Location:141
    SPATA6; Spermatogenesis-assoc protein 6
  2. XM_006503347.5XP_006503410.1  spermatogenesis-associated protein 6 isoform X2

    Conserved Domains (1) summary
    pfam14909
    Location:141
    SPATA6; Spermatogenesis-assoc protein 6
  3. XM_006503348.5XP_006503411.1  spermatogenesis-associated protein 6 isoform X3

    Conserved Domains (1) summary
    pfam14909
    Location:321
    SPATA6; Spermatogenesis-assoc protein 6
  4. XM_030253731.2XP_030109591.1  spermatogenesis-associated protein 6 isoform X2

    Conserved Domains (1) summary
    pfam14909
    Location:141
    SPATA6; Spermatogenesis-assoc protein 6
  5. XM_006503346.5XP_006503409.1  spermatogenesis-associated protein 6 isoform X1

    Conserved Domains (1) summary
    pfam14909
    Location:1179
    SPATA6; Spermatogenesis-assoc protein 6