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Ppa1 pyrophosphatase (inorganic) 1 [ Mus musculus (house mouse) ]

Gene ID: 67895, updated on 18-Apr-2024

Summary

Official Symbol
Ppa1provided by MGI
Official Full Name
pyrophosphatase (inorganic) 1provided by MGI
Primary source
MGI:MGI:97831
See related
Ensembl:ENSMUSG00000020089 AllianceGenome:MGI:97831
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pyp; 2010317E03Rik
Summary
Enables pyrophosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cranium; integumental system; sensory organ; and telencephalon. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 58.9), CNS E18 (RPKM 48.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 B4; 10 32.25 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61484400..61509944)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61648621..61674165)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 20 Neighboring gene oligosaccharyltransferase complex subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_26850 Neighboring gene predicted gene 28447 Neighboring gene neuropeptide FF receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10613 Neighboring gene STARR-positive B cell enhancer ABC_E6861 Neighboring gene RIKEN cDNA 1700022H01 gene Neighboring gene STARR-positive B cell enhancer ABC_E9032 Neighboring gene secretion associated Ras related GTPase 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inorganic diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables pyrophosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inorganic pyrophosphatase
Names
PPase
pyrophosphate phospho-hydrolase
NP_080714.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026438.4NP_080714.2  inorganic pyrophosphatase

    See identical proteins and their annotated locations for NP_080714.2

    Status: PROVISIONAL

    Source sequence(s)
    AC124421
    Consensus CDS
    CCDS23882.1
    UniProtKB/Swiss-Prot
    Q9D819
    UniProtKB/TrEMBL
    Q3UA53, Q4FK49
    Related
    ENSMUSP00000020286.7, ENSMUST00000020286.7
    Conserved Domains (1) summary
    cl00217
    Location:4241
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    61484400..61509944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)