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Coa6 cytochrome c oxidase assembly factor 6 [ Mus musculus (house mouse) ]

Gene ID: 67892, updated on 26-Sep-2022

Summary

Official Symbol
Coa6provided by MGI
Official Full Name
cytochrome c oxidase assembly factor 6provided by MGI
Primary source
MGI:MGI:1915142
See related
Ensembl:ENSMUSG00000051671 AllianceGenome:MGI:1915142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810063B05Rik
Summary
Predicted to enable copper ion binding activity. Predicted to be involved in mitochondrial ATP synthesis coupled electron transport; plasma membrane ATP synthesis coupled electron transport; and respiratory chain complex IV assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 4. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 35.5), adrenal adult (RPKM 29.9) and 28 other tissues See more
Orthologs
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Genomic context

See Coa6 in Genome Data Viewer
Location:
8; 8 E2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (127149240..127152174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (126422501..126425435)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F3 Neighboring gene predicted gene, 53471 Neighboring gene predicted gene, 51604 Neighboring gene TAR RNA binding protein 1 Neighboring gene thymidine kinase 1 pseudogene Neighboring gene predicted gene, 51605

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome c oxidase assembly factor 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174987.5NP_778152.1  cytochrome c oxidase assembly factor 6 homolog

    See identical proteins and their annotated locations for NP_778152.1

    Status: VALIDATED

    Source sequence(s)
    AC151908
    Consensus CDS
    CCDS52709.1
    UniProtKB/Swiss-Prot
    Q8BGD8
    UniProtKB/TrEMBL
    A0A8C6HTQ0
    Related
    ENSMUSP00000058279.5, ENSMUST00000059093.7
    Conserved Domains (1) summary
    cd00926
    Location:464
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    127149240..127152174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)