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Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 67886, updated on 12-May-2024

Summary

Official Symbol
Camsap2provided by MGI
Official Full Name
calmodulin regulated spectrin-associated protein family, member 2provided by MGI
Primary source
MGI:MGI:1922434
See related
Ensembl:ENSMUSG00000041570 AllianceGenome:MGI:1922434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camsap1l1; mKIAA1078; 1600013L13Rik; 4930541M15Rik
Summary
Enables microtubule minus-end binding activity. Involved in regulation of organelle organization. Located in ciliary basal body and microtubule minus-end. Is expressed in jaw bone; liver; lung; nervous system; and neural retina. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.4), whole brain E14.5 (RPKM 11.7) and 25 other tissues See more
Orthologs
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Genomic context

See Camsap2 in Genome Data Viewer
Location:
1 E4; 1 59.61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136195861..136273855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136268123..136346117, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02404 Neighboring gene innate immunity activator Neighboring gene predicted gene 3878 Neighboring gene G protein-coupled receptor 25 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene STARR-seq mESC enhancer starr_02406 Neighboring gene DEAD box helicase 59 Neighboring gene STARR-positive B cell enhancer ABC_E993 Neighboring gene kinesin family member 14 Neighboring gene predicted gene 29485

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule minus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables spectrin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon development ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of organelle organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of organelle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule end ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule minus-end IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule minus-end IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule minus-end ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calmodulin-regulated spectrin-associated protein 2
Names
calmodulin-regulated spectrin-associated protein 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347109.1NP_001334038.1  calmodulin-regulated spectrin-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120875, AC124550
    Consensus CDS
    CCDS83598.1
    UniProtKB/TrEMBL
    A0A0A6YY67, B2RRE3
    Related
    ENSMUSP00000142299.2, ENSMUST00000192314.2
  2. NM_001347110.1NP_001334039.1  calmodulin-regulated spectrin-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120875, AC124550
    Consensus CDS
    CCDS83597.1
    UniProtKB/Swiss-Prot
    B7ZNI4, Q80TK8, Q8C1B1, Q8C4J5
    UniProtKB/TrEMBL
    B2RRE3
    Related
    ENSMUSP00000142166.2, ENSMUST00000192001.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136195861..136273855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529832.3XP_006529895.1  calmodulin-regulated spectrin-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    B2RRE3
    Conserved Domains (4) summary
    PHA03247
    Location:9171028
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:237315
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:13421460
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:731789
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  2. XM_006529834.4XP_006529897.1  calmodulin-regulated spectrin-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    B2RRE3
    Conserved Domains (4) summary
    PHA03247
    Location:9061017
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:226304
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:13311449
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:720778
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  3. XM_011248066.4XP_011246368.1  calmodulin-regulated spectrin-associated protein 2 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:515626
    PHA03247; large tegument protein UL36; Provisional
    pfam08683
    Location:9401058
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:329387
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
  4. XM_036153216.1XP_036009109.1  calmodulin-regulated spectrin-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    B2RRE3
    Conserved Domains (3) summary
    PHA03247
    Location:9171028
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:237315
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:731789
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

RNA

  1. XR_004934125.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081360.1: Suppressed sequence

    Description
    NM_001081360.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.