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Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 67886, updated on 8-Jan-2023

Summary

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Official Symbol
Camsap2provided by MGI
Official Full Name
calmodulin regulated spectrin-associated protein family, member 2provided by MGI
Primary source
MGI:MGI:1922434
See related
Ensembl:ENSMUSG00000041570 AllianceGenome:MGI:1922434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camsap1l1; mKIAA1078; 1600013L13Rik; 4930541M15Rik
Summary
Enables microtubule minus-end binding activity. Involved in regulation of organelle organization. Located in ciliary basal body and microtubule minus-end. Is expressed in jaw bone; liver; lung; nervous system; and neural retina. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.4), whole brain E14.5 (RPKM 11.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Camsap2 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136195861..136273855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136268123..136346117, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene innate immunity activator Neighboring gene predicted gene 3878 Neighboring gene G protein-coupled receptor 25 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene DEAD box helicase 59 Neighboring gene kinesin family member 14 Neighboring gene predicted gene 29485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Wang X, et al. Sci Rep, 2022 Oct 7. PMID 36207462, Free PMC Article
  2. CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells. Coquand L, et al. J Cell Biol, 2021 Aug 2. PMID 34019079, Free PMC Article
  3. CAMSAP3 maintains neuronal polarity through regulation of microtubule stability. Pongrakhananon V, et al. Proc Natl Acad Sci U S A, 2018 Sep 25. PMID 30190432, Free PMC Article
  4. CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia. Robinson AM, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32482850, Free PMC Article
  5. Loss of CAMSAP3 promotes EMT via the modification of microtubule-Akt machinery. Pongrakhananon V, et al. J Cell Sci, 2018 Oct 29. PMID 30282632

See all (29) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
    Title: CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
  2. CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
    Title: CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
  3. CAMSAP2 and -3 work together to maintain noncentrosomal microtubules in epithelial cells, suppressing the microtubule-organizing ability of the centrosome.
    Title: Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables microtubule minus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables spectrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon development ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of organelle organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of organelle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule end ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule minus-end IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in microtubule minus-end IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule minus-end ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calmodulin-regulated spectrin-associated protein 2
Names
calmodulin-regulated spectrin-associated protein 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347109.1 → NP_001334038.1  calmodulin-regulated spectrin-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120875, AC124550
    Consensus CDS
    CCDS83598.1
    UniProtKB/TrEMBL
    A0A0A6YY67
    Related
    ENSMUSP00000142299.2, ENSMUST00000192314.2

  2. NM_001347110.1 → NP_001334039.1  calmodulin-regulated spectrin-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120875, AC124550
    Consensus CDS
    CCDS83597.1
    UniProtKB/Swiss-Prot
    Q8C1B1, Q8C4J5
    Related
    ENSMUSP00000142166.2, ENSMUST00000192001.6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136195861..136273855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529832.3 → XP_006529895.1  calmodulin-regulated spectrin-associated protein 2 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:917 → 1028
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:237 → 315
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:1342 → 1460
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:731 → 789
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  2. XM_006529834.4 → XP_006529897.1  calmodulin-regulated spectrin-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8C1B1
    Conserved Domains (4) summary
    PHA03247
    Location:906 → 1017
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:226 → 304
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:1331 → 1449
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:720 → 778
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  3. XM_011248066.4 → XP_011246368.1  calmodulin-regulated spectrin-associated protein 2 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:515 → 626
    PHA03247; large tegument protein UL36; Provisional
    pfam08683
    Location:940 → 1058
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:329 → 387
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  4. XM_036153216.1 → XP_036009109.1  calmodulin-regulated spectrin-associated protein 2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:917 → 1028
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:237 → 315
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:731 → 789
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

RNA

  1. XR_004934125.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081360.1: Suppressed sequence

    Description
    NM_001081360.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1B1.3 GenPept UniProtKB/Swiss-Prot:Q8C1B1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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