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Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 67877, updated on 6-Nov-2022

Summary

Official Symbol
Naa20provided by MGI
Official Full Name
N(alpha)-acetyltransferase 20, NatB catalytic subunitprovided by MGI
Primary source
MGI:MGI:1915127
See related
Ensembl:ENSMUSG00000002728 AllianceGenome:MGI:1915127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nat5; D2Ertd186e; 1500004D14Rik; 2900026I01Rik
Summary
Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of NatB complex. Is expressed in several structures, including alimentary system; brain; heart; retina; and skin. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.7), placenta adult (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See Naa20 in Genome Data Viewer
Location:
2 G1; 2 71.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145743454..145758345)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145901539..145916425)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 2 Neighboring gene predicted gene, 54121 Neighboring gene predicted gene, 39954 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene cilia and flagella associated protein 61 Neighboring gene predicted gene, 34629

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC144325

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NatB complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 20
Names
N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
N-terminal acetyltransferase B complex catalytic subunit NAA20
N-terminal acetyltransferase B complex catalytic subunit NAT5
methionine N-acetyltransferase
natB catalytic subunit
natB complex subunit NAT5
NP_001135437.1
NP_080701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141965.1NP_001135437.1  N-alpha-acetyltransferase 20 isoform 1

    See identical proteins and their annotated locations for NP_001135437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK005143, AK009229, CO802916
    Consensus CDS
    CCDS50735.1
    UniProtKB/Swiss-Prot
    P61600
    UniProtKB/TrEMBL
    A0A6P5R2P6, A0A8C6H7Z2, Q9DB82
    Related
    ENSMUSP00000105627.2, ENSMUST00000110000.8
    Conserved Domains (1) summary
    COG0456
    Location:1156
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
  2. NM_026425.3NP_080701.1  N-alpha-acetyltransferase 20 isoform 2

    See identical proteins and their annotated locations for NP_080701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an in-frame alternate splice site in the coding region, compared to variant 1, and encodes a longer protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK005143, AK009229, CO802916
    Consensus CDS
    CCDS16827.1
    UniProtKB/Swiss-Prot
    P61600
    UniProtKB/TrEMBL
    A0A6P5R2P4, Q9DB82
    Related
    ENSMUSP00000002805.8, ENSMUST00000002805.14
    Conserved Domains (1) summary
    COG0456
    Location:1166
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145743454..145758345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003953700.2 RNA Sequence