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CLN6 CLN6 transmembrane ER protein [ Ovis aries (sheep) ]

Gene ID: 678673, updated on 10-Sep-2025
Gene symbol
CLN6
Gene description
CLN6 transmembrane ER protein
See related
Ensembl:ENSOARG00020069458
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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See CLN6 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (15012915..15028256, complement)

Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 1 Neighboring gene calmodulin like 4 Neighboring gene uncharacterized LOC105608741 Neighboring gene fem-1 homolog B

Genomic Sequence:
NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Ovis aries Rambouillet Genome sequencing and assembly
  • BioProject: PRJNA414087
  • Analysis date: Thu Jan 09 10:41:41 2025

Related articles in PubMed

  1. Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis. Kanninen KM, et al. PLoS One, 2013. PMID 23516525, Free PMC Article
  2. The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction. Kay GW, et al. Neurobiol Dis, 2011 Mar. PMID 21111820
  3. Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis. Oswald MJ, et al. Neurobiol Dis, 2008 Oct. PMID 18634879, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. altered metal concentrations, synaptic protein changes, and aberrant modulation of cellular signaling pathways are characteristic features in the CLN6 ovine form of neuronal ceroid lipofuscinosis
    Title: Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
  2. In this animal model, physiological functionality and connectivity, not genotype, determine neuron fate in CLN6 ceroid-lipofuscinosis.
    Title: The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction.
  3. In this report, a comprehensive survey of interneuron phenotypes in CLN6-affected sheep highlights cellular location and interconnectivity as the major determinants of neuron survival, rather than phenotype.
    Title: Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis.
Submit: New GeneRIF Correction

Homology

Preferred Names
ceroid-lipofuscinosis neuronal protein 6
Names
ceroid-lipofuscinosis, neuronal 6, late infantile
NP_001035379.1

Length

  • 310

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040289.1 → NP_001035379.1  ceroid-lipofuscinosis neuronal protein 6

    See identical proteins and their annotated locations for NP_001035379.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ458790
    UniProtKB/TrEMBL
    A0A6P3CWL8, A0A836D000, Q1PAG8
    Related
    ENSOARP00020098618.1, ENSOART00020084429.1
    Conserved Domains (1) summary
    pfam15156
    Location:30 → 309
    CLN6; Ceroid-lipofuscinosis neuronal protein 6

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    15012915..15028256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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