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SULT1E1 sulfotransferase family 1E member 1 [ Homo sapiens (human) ]

Gene ID: 6783, updated on 7-Dec-2018

Summary

Official Symbol
SULT1E1provided by HGNC
Official Full Name
sulfotransferase family 1E member 1provided by HGNC
Primary source
HGNC:HGNC:11377
See related
Ensembl:ENSG00000109193 MIM:600043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EST; STE; EST-1; ST1E1
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues See more
Orthologs

Genomic context

See SULT1E1 in Genome Data Viewer
Location:
4q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (69841212..69860152, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70706930..70725870, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1B member 1 Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene casein alpha s1 Neighboring gene casein beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
    Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
  • Estrogen metabolism, organism-specific biosystem (from WikiPathways)
    Estrogen metabolism, organism-specific biosystem
    Estrogen metabolism
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
  • Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
    Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Steroid hormone biosynthesis, conserved biosystem (from KEGG)
    Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Sulfation Biotransformation Reaction, organism-specific biosystem (from WikiPathways)
    Sulfation Biotransformation Reaction, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...
  • Tamoxifen metabolism, organism-specific biosystem (from WikiPathways)
    Tamoxifen metabolism, organism-specific biosystem
    Tamoxifen metabolism

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aryl sulfotransferase activity TAS
Traceable Author Statement
more info
 
estrone sulfotransferase activity TAS
Traceable Author Statement
more info
 
flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid sulfotransferase activity TAS
Traceable Author Statement
more info
 
sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
estrogen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
estrogen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
estrogen sulfotransferase
Names
estrone sulfotransferase
sulfotransferase 1E1
sulfotransferase family 1E, estrogen-preferring, member 1
sulfotransferase, estrogen-preferring
NP_005411.1
XP_011530512.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005420.3NP_005411.1  estrogen sulfotransferase

    See identical proteins and their annotated locations for NP_005411.1

    Status: REVIEWED

    Source sequence(s)
    AC108941
    Consensus CDS
    CCDS3531.1
    UniProtKB/Swiss-Prot
    P49888
    UniProtKB/TrEMBL
    Q53X91
    Related
    ENSP00000226444.3, ENST00000226444.3
    Conserved Domains (1) summary
    pfam00685
    Location:37287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    69841212..69860152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532210.2XP_011530512.1  estrogen sulfotransferase isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:37165
    Sulfotransfer_1; Sulfotransferase domain
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