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SULT1E1 sulfotransferase family 1E member 1 [ Homo sapiens (human) ]

Gene ID: 6783, updated on 17-Oct-2021

Summary

Official Symbol
SULT1E1provided by HGNC
Official Full Name
sulfotransferase family 1E member 1provided by HGNC
Primary source
HGNC:HGNC:11377
See related
Ensembl:ENSG00000109193 MIM:600043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EST; STE; EST-1; ST1E1
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues See more
Orthologs
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Genomic context

See SULT1E1 in Genome Data Viewer
Location:
4q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (69841212..69860151, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70706930..70725863, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10246 Neighboring gene casein alpha s1 Neighboring gene casein beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables estrone sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sulfotransferase 1E1
Names
estrogen sulfotransferase
estrone sulfotransferase
sulfotransferase family 1E, estrogen-preferring, member 1
sulfotransferase, estrogen-preferring
NP_005411.1
XP_011530512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005420.3NP_005411.1  sulfotransferase 1E1

    See identical proteins and their annotated locations for NP_005411.1

    Status: REVIEWED

    Source sequence(s)
    AC108941
    Consensus CDS
    CCDS3531.1
    UniProtKB/Swiss-Prot
    P49888
    UniProtKB/TrEMBL
    Q53X91
    Related
    ENSP00000226444.3, ENST00000226444.4
    Conserved Domains (1) summary
    pfam00685
    Location:37287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    69841212..69860151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532210.2XP_011530512.1  sulfotransferase 1E1 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:37165
    Sulfotransfer_1; Sulfotransferase domain
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