Pllp plasma membrane proteolipid [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pllpprovided by MGI
Official Full Name: plasma membrane proteolipidprovided by MGI
Primary source: MGI:MGI:1915051
See related: Ensembl:ENSMUSG00000031775 AllianceGenome:MGI:1915051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plapi; Tm4sf11; 0610010I06Rik
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in monoatomic ion transport and myelination. Predicted to act upstream of or within regulation of endocytosis. Predicted to be located in compact myelin. Predicted to be active in membrane. Is expressed in midgut; olfactory epithelium; and stomach. Orthologous to human PLLP (plasmolipin). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in colon adult (RPKM 151.5), stomach adult (RPKM 151.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95401523..95422870, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94674895..94696242, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLLP recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis.
Title: Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.
mouse PLLP also functioned well as a receptor for McERV but was simply not expressed in the mouse cell types that we originally tested.
Title: Identification of the myelin protein plasmolipin as the cell entry receptor for Mus caroli endogenous retrovirus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235965

AV001002 (e-PCR)
- UniSTS:165594

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in myelin assembly	IEA Inferred from Electronic Annotation more info
involved_in myelin assembly	ISO Inferred from Sequence Orthology more info
involved_in myelination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in compact myelin	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasmolipin

Names: transmembrane 4 superfamily member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.