Format

Send to:

Choose Destination

STAU1 staufen double-stranded RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 6780, updated on 1-Aug-2020

Summary

Official Symbol
STAU1provided by HGNC
Official Full Name
staufen double-stranded RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:11370
See related
Ensembl:ENSG00000124214 MIM:601716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAU; PPP1R150
Summary
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]
Expression
Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues See more
Orthologs

Genomic context

See STAU1 in Genome Data Viewer
Location:
20q13.13
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49113339..49219295, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47729876..47804907, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CSE1L antisense RNA 1 Neighboring gene chromosome segregation 1 like Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 1 Neighboring gene DEAD-box helicase 27 Neighboring gene zinc finger NFX1-type containing 1 Neighboring gene Sharpr-MPRA regulatory region 13855 Neighboring gene ZNFX1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Staufen1, vRNA and Gag are found in the same ribonucleoprotein (RNP) complex. The depletion of Staufen1 results in reduced Gag levels and deregulates the assembly of newly synthesized virions PubMed
gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
gag Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
gag EAP30 interacts with HIV-1 Gag and Staufen1 in live cell tri-molecular fluorescence complementary assay PubMed
gag HIV-1 Gag and Stau1 interact in both membrane-associated and cytosolic complexes. Stau1 overexpression and depletion by RNAi modulate Gag multimerization PubMed
gag The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization PubMed
nucleocapsid gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
gag The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
modification of postsynaptic structure IEA
Inferred from Electronic Annotation
more info
 
positive regulation by virus of viral protein levels in host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
double-stranded RNA-binding protein Staufen homolog 1
Names
protein phosphatase 1, regulatory subunit 150
staufen, RNA binding protein, homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029453.2 RefSeqGene

    Range
    45926..120957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001037328.2NP_001032405.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

    See identical proteins and their annotated locations for NP_001032405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).
    Source sequence(s)
    AF061938, AK091405, BC010169, BC095397, BE439382, DB100321
    Consensus CDS
    CCDS33481.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0, Q6PJX3
    Conserved Domains (3) summary
    smart00358
    Location:105175
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:211277
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:373482
    Staufen_C; Staufen C-terminal domain
  2. NM_001319134.1NP_001306063.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T6) uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).
    Source sequence(s)
    AK091405, AY546099, BE439382, BQ649508, DB100321
    Consensus CDS
    CCDS33481.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0
    Related
    ENSP00000360893.3, ENST00000371828.7
    Conserved Domains (3) summary
    smart00358
    Location:105175
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:211277
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:373482
    Staufen_C; Staufen C-terminal domain
  3. NM_001319135.1NP_001306064.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T7) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).
    Source sequence(s)
    AB209561, AK091405, BE439382, BQ649508, DB086071
    Consensus CDS
    CCDS13414.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0, Q59F99
    Conserved Domains (3) summary
    smart00358
    Location:186250
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:286352
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:448557
    Staufen_C; Staufen C-terminal domain
  4. NM_001322927.1NP_001309856.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473, DA858410
    Consensus CDS
    CCDS33481.1
    UniProtKB/Swiss-Prot
    O95793
    Related
    ENSP00000360867.1, ENST00000371802.5
    Conserved Domains (3) summary
    smart00358
    Location:105175
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:211277
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:373482
    Staufen_C; Staufen C-terminal domain
  5. NM_001322928.1NP_001309857.1  double-stranded RNA-binding protein Staufen homolog 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473, DA858410
    Conserved Domains (3) summary
    smart00358
    Location:145215
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:251317
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:413522
    Staufen_C; Staufen C-terminal domain
  6. NM_001322929.1NP_001309858.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473
    Consensus CDS
    CCDS13414.1
    UniProtKB/Swiss-Prot
    O95793
    Conserved Domains (3) summary
    smart00358
    Location:186250
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:286352
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:448557
    Staufen_C; Staufen C-terminal domain
  7. NM_001322930.1NP_001309859.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473
    Consensus CDS
    CCDS13414.1
    UniProtKB/Swiss-Prot
    O95793
    Conserved Domains (3) summary
    smart00358
    Location:186250
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:286352
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:448557
    Staufen_C; Staufen C-terminal domain
  8. NM_001322931.1NP_001309860.1  double-stranded RNA-binding protein Staufen homolog 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473, DA858410
  9. NM_001322932.1NP_001309861.1  double-stranded RNA-binding protein Staufen homolog 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473
    Conserved Domains (3) summary
    smart00358
    Location:186256
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:292358
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:454563
    Staufen_C; Staufen C-terminal domain
  10. NM_001322933.1NP_001309862.1  double-stranded RNA-binding protein Staufen homolog 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL133174, BE439382, DA455473
    Conserved Domains (3) summary
    smart00358
    Location:186256
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:292358
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:454563
    Staufen_C; Staufen C-terminal domain
  11. NM_004602.3NP_004593.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

    See identical proteins and their annotated locations for NP_004593.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T4) has an additional exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T4 encodes the same isoform (a) of 496 amino acids as T2.
    Source sequence(s)
    AF061941, AK091405, BC001893, BC050432, BC095397, BE439382, DB100321
    Consensus CDS
    CCDS13415.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0
    Related
    ENSP00000345425.6, ENST00000340954.11
    Conserved Domains (3) summary
    smart00358
    Location:105169
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:205271
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:367476
    Staufen_C; Staufen C-terminal domain
  12. NM_017452.3NP_059346.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

    See identical proteins and their annotated locations for NP_059346.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T2) is most abundantly expressed, and encodes the protein isoform (a) of 496 amino acids.
    Source sequence(s)
    AK091405, BC050432, BC095397, BE439382, DB100321
    Consensus CDS
    CCDS13415.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0
    Related
    ENSP00000353604.4, ENST00000360426.8
    Conserved Domains (3) summary
    smart00358
    Location:105169
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:205271
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:367476
    Staufen_C; Staufen C-terminal domain
  13. NM_017453.4NP_059347.2  double-stranded RNA-binding protein Staufen homolog 1 isoform b

    See identical proteins and their annotated locations for NP_059347.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T3) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).
    Source sequence(s)
    AL133174
    Consensus CDS
    CCDS13414.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0
    Related
    ENSP00000360922.2, ENST00000371856.6
    Conserved Domains (3) summary
    smart00358
    Location:186250
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:286352
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:448557
    Staufen_C; Staufen C-terminal domain
  14. NM_017454.3NP_059348.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

    See identical proteins and their annotated locations for NP_059348.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (T1) lacks an exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T1 encodes the same isoform (a) of 496 amino acids as T2.
    Source sequence(s)
    AK091405, BC050432, BC095397, BE439382, DB100321
    Consensus CDS
    CCDS13415.1
    UniProtKB/Swiss-Prot
    O95793
    UniProtKB/TrEMBL
    B3KRE0
    Related
    ENSP00000323443.7, ENST00000347458.9
    Conserved Domains (3) summary
    smart00358
    Location:105169
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:205271
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:367476
    Staufen_C; Staufen C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49113339..49219295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028028.1XP_016883517.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X3

  2. XM_006723865.1XP_006723928.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006723928.1

    Conserved Domains (3) summary
    smart00358
    Location:186256
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:292358
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:454563
    Staufen_C; Staufen C-terminal domain
  3. XM_005260527.1XP_005260584.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

    See identical proteins and their annotated locations for XP_005260584.1

    UniProtKB/Swiss-Prot
    O95793
    Conserved Domains (3) summary
    smart00358
    Location:105175
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:211277
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:373482
    Staufen_C; Staufen C-terminal domain
  4. XM_011529015.1XP_011527317.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_011527317.1

    Conserved Domains (3) summary
    smart00358
    Location:145215
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:251317
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:413522
    Staufen_C; Staufen C-terminal domain
  5. XM_024451973.1XP_024307741.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X5

    Related
    ENSP00000484011.1, ENST00000614381.4
    Conserved Domains (3) summary
    smart00358
    Location:105169
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:205271
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:367476
    Staufen_C; Staufen C-terminal domain
Support Center