STATH statherin [Homo sapiens (human)] - Gene

Summary

Official Symbol: STATHprovided by HGNC
Official Full Name: statherinprovided by HGNC
Primary source: HGNC:HGNC:11369
See related: Ensembl:ENSG00000126549 MIM:184470; AllianceGenome:HGNC:11369
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STR
Summary: Predicted to enable extracellular matrix constituent, lubricant activity and hydroxyapatite binding activity. Predicted to be a structural constituent of tooth enamel. Predicted to be involved in negative regulation of bone mineralization; ossification; and saliva secretion. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward salivary gland (RPKM 34203.8) See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 4q13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (69995966..70002570)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (73330761..73337367)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (70861683..70868287)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis.
Title: Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis.
A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis.
Title: A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis.
The total protein and statherin in the in-vivo AEP were different between eroded and non-eroded tooth surfaces of the same patient
Title: Reduced statherin in acquired enamel pellicle on eroded teeth compared to healthy teeth in the same subjects: An in-vivo study.
effects of statherin on intracellular calcium level and its subsequent related molecular alterations would give us new pathogenic aspect in oral carcinogenesis
Title: Role of statherin in oral carcinogenesis.
phenylalanine orientations in statherin bound to hydroxyapatite surfaces
Title: Direct observation of phenylalanine orientations in statherin bound to hydroxyapatite surfaces.
Data show that the full characterization of the statherin peptides generated facilitates the elucidation of their novel functional roles in the oral and gastro-intestinal environment.
Title: Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
insight into the molecular interactions of statherin with hydroxyapatite surfaces
Title: A (13)C{(31)P} REDOR NMR investigation of the role of glutamic acid residues in statherin- hydroxyapatite recognition.
In conclusion, statherin induces transition to yeast of Candida albicans hyphae and may thus contribute to the oral defense against candidiasis.
Title: Identification of salivary components that induce transition of hyphae to yeast in Candida albicans.
inhibits calcium phosphate precipitation
Title: Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif upregulates the expression of statherin (STATH) in Vif-expression T cells	PubMed

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-59549 (e-PCR)
- UniSTS:40360

SGC35622 (e-PCR)
- UniSTS:51645

D4S2814 (e-PCR)
- UniSTS:10441

SHGC4-1838 (e-PCR)
- UniSTS:183803

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables extracellular matrix constituent, lubricant activity	NAS Non-traceable Author Statement more info	PubMed
enables hydroxyapatite binding	IEA Inferred from Electronic Annotation more info
enables hydroxyapatite binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of tooth enamel	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone mineralization	NAS Non-traceable Author Statement more info	PubMed
involved_in ossification	TAS Traceable Author Statement more info	PubMed
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in saliva secretion	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: statherin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009181.2 → NP_001009181.1 statherin isoform b precursor

See identical proteins and their annotated locations for NP_001009181.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b, which is shorter than isoform a.

Source sequence(s)

AC063956, BC067219, CB958641, CB986973

Consensus CDS

CCDS33998.1

UniProtKB/Swiss-Prot

P02808

Related

ENSP00000370448.2, ENST00000381060.2
NM_003154.3 → NP_003145.1 statherin isoform a precursor

See identical proteins and their annotated locations for NP_003145.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC063956, BC067219, CB958641, CB986973

Consensus CDS

CCDS3533.1

UniProtKB/Swiss-Prot

A6NKE9, B2R4F8, P02808

Related

ENSP00000246895.4, ENST00000246895.9

Conserved Domains (1) summary

pfam03875
Location:20 → 50

Statherin