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Sfr1 SWI5 dependent recombination repair 1 [ Mus musculus (house mouse) ]

Gene ID: 67788, updated on 30-Apr-2024

Summary

Official Symbol
Sfr1provided by MGI
Official Full Name
SWI5 dependent recombination repair 1provided by MGI
Primary source
MGI:MGI:1915038
See related
Ensembl:ENSMUSG00000025066 AllianceGenome:MGI:1915038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meir5; 6330577E15Rik
Summary
Predicted to enable nuclear receptor coactivator activity. Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in olfactory cortex ventricular layer; pancreas epithelium; and telencephalon ventricular layer. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 57.4), CNS E11.5 (RPKM 54.6) and 28 other tissues See more
Orthologs
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Genomic context

See Sfr1 in Genome Data Viewer
Location:
19 D1; 19 40.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47720159..47724027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47731714..47735588)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26085 Neighboring gene predicted gene, 24805 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47805577-47805764 Neighboring gene STARR-positive B cell enhancer ABC_E8756 Neighboring gene STARR-seq mESC enhancer starr_46368 Neighboring gene cilia and flagella associated protein 43 Neighboring gene microRNA 8090 Neighboring gene STARR-seq mESC enhancer starr_46371 Neighboring gene STARR-positive B cell enhancer ABC_E2529 Neighboring gene STARR-seq mESC enhancer starr_46373 Neighboring gene STARR-seq mESC enhancer starr_46374 Neighboring gene predicted gene, 30021

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Swi5-Sfr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Swi5-Sfr1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Swi5-Sfr1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
swi5-dependent recombination DNA repair protein 1 homolog
Names
DNA repair protein Sfr1
meiosis protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026377.2NP_080653.2  swi5-dependent recombination DNA repair protein 1 homolog

    See identical proteins and their annotated locations for NP_080653.2

    Status: VALIDATED

    Source sequence(s)
    AK011531, AK146810, AV335878
    Consensus CDS
    CCDS38019.1
    UniProtKB/Swiss-Prot
    Q3TH62, Q3TI03, Q3TJK0, Q3UIQ6, Q8BP27, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4
    UniProtKB/TrEMBL
    E3WH30
    Related
    ENSMUSP00000096954.5, ENSMUST00000099353.6
    Conserved Domains (1) summary
    pfam10376
    Location:108310
    Mei5; Double-strand recombination repair protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47720159..47724027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527308.4XP_006527371.1  swi5-dependent recombination DNA repair protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    E3WH30
    Conserved Domains (1) summary
    pfam10376
    Location:96298
    Mei5; Double-strand recombination repair protein