Kat8 K(lysine) acetyltransferase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat8provided by MGI
Official Full Name: K(lysine) acetyltransferase 8provided by MGI
Primary source: MGI:MGI:1915023
See related: Ensembl:ENSMUSG00000030801 AllianceGenome:MGI:1915023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MOF; Myst1; MYST-1; D7Ertd629e; 2010203C02Rik; 5830450F21Rik
Summary: Enables enzyme binding activity and histone acetyltransferase activity (H4-K16 specific). Involved in histone H4-K16 acetylation. Located in kinetochore and nuclear matrix. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; limb; nervous system; and respiratory system. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 32.3), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127511689..127525010)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127912517..127925838)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness.
Title: MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness.
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
Title: Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
Title: Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
Mof regulates glucose level via altering different alpha-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion.
Title: Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion.
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Title: A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
KAT8 is down-regulating virus-induced IFN-I production by acetylating the transcription factor IRF3 at lysine 359, inhibiting the recruitment of IRF3 to IFN-I promoters, and decreasing its transcriptional activity.
Title: KAT8 selectively inhibits antiviral immunity by acetylating IRF3.
Loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation of nuclear abnormalities with genomic instability patterns including chromothripsis.
Title: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
MOF modulates expression of a subset of endogenous genes regulated by ER-alpha.
Title: Histone acetyltransferase MOF is involved in suppression of endometrial cancer and maintenance of ERα stability.
Study utilizing Mof knockout mice demonstrate that MLL4 co-localizes with H4K16ac in vivo and that the association of MLL4 with a set of genomic targets is Mof dependent and requires the acetyltransferase activity of Mof.
Title: Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.
MOF regulates male meiosis and is involved in the expansion of all three waves of H2AX phosphorylation from the leptotene to pachytene stages, initiated by ATM and ATR, respectively.
Title: MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126736 (e-PCR)
- UniSTS:208208

RH136638 (e-PCR)
- UniSTS:218729

D7Ertd629e (e-PCR), detects polymorphism
- UniSTS:167533

AI313909 (e-PCR)
- UniSTS:159695

RH135325 (e-PCR)
- UniSTS:218602

Homology

Homologs of the Kat8 gene: The Kat8 gene is conserved in human, chimpanzee, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 409 organisms have orthologs with human gene Kat8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H4K16 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in histone H4-K16 acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone H4-K5 acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone H4-K8 acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone acetylation	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of histone H3-K4 methylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of dosage compensation by inactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MSL complex	ISO Inferred from Sequence Orthology more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone acetyltransferase KAT8

Names: MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; histone acetyltransferase Myst1; lysine acetyltransferase 8; probable histone acetyltransferase MYST1

NP_001347628.1

EC 2.3.1.48

NP_080646.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360699.1 → NP_001347628.1 histone acetyltransferase KAT8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC149222

Conserved Domains (1) summary

PLN00104
Location:6 → 291

PLN00104; MYST -like histone acetyltransferase; Provisional
NM_026370.2 → NP_080646.1 histone acetyltransferase KAT8 isoform 1

See identical proteins and their annotated locations for NP_080646.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK132000, AK146710

Consensus CDS

CCDS21885.1

UniProtKB/Swiss-Prot

Q8CI73, Q9D1P2

UniProtKB/TrEMBL

A0A6P5PVK3, A0A8C6I0N4

Related

ENSMUSP00000033070.8, ENSMUST00000033070.9

Conserved Domains (1) summary

PLN00104
Location:21 → 449

PLN00104; MYST -like histone acetyltransferase; Provisional