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Caap1 caspase activity and apoptosis inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 67770, updated on 6-Jun-2024

Summary

Official Symbol
Caap1provided by MGI
Official Full Name
caspase activity and apoptosis inhibitor 1provided by MGI
Primary source
MGI:MGI:1915020
See related
Ensembl:ENSMUSG00000028578 AllianceGenome:MGI:1915020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAAP; 5830433M19Rik
Summary
Predicted to be involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.2), bladder adult (RPKM 2.8) and 28 other tissues See more
Orthologs
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Genomic context

See Caap1 in Genome Data Viewer
Location:
4 C5; 4 43.32 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94388318..94445033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94500079..94556796, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12655 Neighboring gene STARR-seq mESC enhancer starr_10787 Neighboring gene STARR-seq mESC enhancer starr_10788 Neighboring gene predicted gene 12656 Neighboring gene phospholipase A2, activating protein Neighboring gene STARR-positive B cell enhancer ABC_E3497 Neighboring gene H3.5 histone Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
caspase activity and apoptosis inhibitor 1
Names
conserved anti-apoptotic protein
likely ortholog of H. sapiens chromosome 9 open reading frame 82 (C9orf82)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001406349.1NP_001393278.1  caspase activity and apoptosis inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807252
  2. NM_001406350.1NP_001393279.1  caspase activity and apoptosis inhibitor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807252
  3. NM_001406351.1NP_001393280.1  caspase activity and apoptosis inhibitor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807252
    UniProtKB/TrEMBL
    Q3TUU0
  4. NM_026368.3NP_080644.2  caspase activity and apoptosis inhibitor 1 isoform 1

    See identical proteins and their annotated locations for NP_080644.2

    Status: VALIDATED

    Source sequence(s)
    AL807252
    Consensus CDS
    CCDS18358.1
    UniProtKB/Swiss-Prot
    Q3USG8, Q8VDY9
    UniProtKB/TrEMBL
    Q3TUU0
    Related
    ENSMUSP00000030313.9, ENSMUST00000030313.9
    Conserved Domains (1) summary
    pfam15335
    Location:114175
    CAAP1; Caspase activity and apoptosis inhibitor 1

RNA

  1. NR_176046.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807252
  2. NR_176047.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807252

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    94388318..94445033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)