Caap1 caspase activity and apoptosis inhibitor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Caap1provided by MGI
Official Full Name: caspase activity and apoptosis inhibitor 1provided by MGI
Primary source: MGI:MGI:1915020
See related: Ensembl:ENSMUSG00000028578 AllianceGenome:MGI:1915020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAAP; 5830433M19Rik
Summary: Predicted to be involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 4.2), bladder adult (RPKM 2.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 C5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (94388315..94445712, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (94500079..94556796, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C9orf82ko/ko mice were born at a Mendelian ratio and did not display any overt macroscopic or histological abnormalities. DNA double-strand breaks repair dependent processes like lymphocyte development and class switch recombination (CSR) appeared normal, arguing against a link between the C9orf82 encoded protein and V(D)J recombination or CSR.
Title: Towards an understanding of C9orf82 protein/CAAP1 function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Caap1 gene: The Caap1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 496 organisms have orthologs with human gene Caap1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: caspase activity and apoptosis inhibitor 1

Names: conserved anti-apoptotic protein; likely ortholog of H. sapiens chromosome 9 open reading frame 82 (C9orf82)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001406349.1 → NP_001393278.1 caspase activity and apoptosis inhibitor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL807252
NM_001406350.1 → NP_001393279.1 caspase activity and apoptosis inhibitor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL807252
NM_001406351.1 → NP_001393280.1 caspase activity and apoptosis inhibitor 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL807252
NM_026368.3 → NP_080644.2 caspase activity and apoptosis inhibitor 1 isoform 1

See identical proteins and their annotated locations for NP_080644.2

Status: VALIDATED

Source sequence(s)

AL807252

Consensus CDS

CCDS18358.1

UniProtKB/Swiss-Prot

Q3USG8, Q8VDY9

UniProtKB/TrEMBL

Q3TUU0

Related

ENSMUSP00000030313.9, ENSMUST00000030313.9

Conserved Domains (1) summary

pfam15335
Location:114 → 175

CAAP1; Caspase activity and apoptosis inhibitor 1