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N6amt1 N-6 adenine-specific DNA methyltransferase 1 (putative) [ Mus musculus (house mouse) ]

Gene ID: 67768, updated on 8-May-2024

Summary

Official Symbol
N6amt1provided by MGI
Official Full Name
N-6 adenine-specific DNA methyltransferase 1 (putative)provided by MGI
Primary source
MGI:MGI:1915018
See related
Ensembl:ENSMUSG00000044442 AllianceGenome:MGI:1915018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hemk2; Pred28; 5830445C04Rik
Summary
Enables protein-glutamine N-methyltransferase activity. Involved in peptidyl-glutamine methylation. Located in nucleus. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.9), ovary adult (RPKM 5.6) and 28 other tissues See more
Orthologs
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Genomic context

See N6amt1 in Genome Data Viewer
Location:
16 C3.3; 16 49.52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87151073..87165537)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87354185..87368649)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32865 Neighboring gene STARR-seq mESC enhancer starr_41394 Neighboring gene predicted gene, 41484 Neighboring gene STARR-seq mESC enhancer starr_41395 Neighboring gene STARR-positive B cell enhancer ABC_E4185 Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1186 Neighboring gene STARR-positive B cell enhancer ABC_E11624 Neighboring gene predicted gene, 25896 Neighboring gene RWD domain containing 2B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC106447

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arsenite methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K12 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-glutamine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-glutamine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of eRF1 methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
methyltransferase N6AMT1
Names
HemK methyltransferase family member 2
M-N6DNA MTase A
N(6)-adenine-specific DNA methyltransferase 1
N6-DNA methyltransferase A
lysine N-methyltransferase 9
methylarsonite methyltransferase N6AMT1
protein N(5)-glutamine methyltransferase
NP_001152803.1
NP_080642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159331.1NP_001152803.1  methyltransferase N6AMT1 isoform 2

    See identical proteins and their annotated locations for NP_001152803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC140319, AY456393
    Consensus CDS
    CCDS49889.1
    UniProtKB/TrEMBL
    Q6PRU9, Q6SKR2
    Related
    ENSMUSP00000113229.2, ENSMUST00000118310.8
    Conserved Domains (1) summary
    cl17173
    Location:21133
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_026366.2NP_080642.1  methyltransferase N6AMT1 isoform 1

    See identical proteins and their annotated locations for NP_080642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140319, AY456393
    Consensus CDS
    CCDS28289.1
    UniProtKB/Swiss-Prot
    D3Z6J0, E9PXT7, Q4KMV5, Q6PRU9, Q6SKR2
    UniProtKB/TrEMBL
    A0A4W7N3B2
    Related
    ENSMUSP00000061835.5, ENSMUST00000054442.11
    Conserved Domains (1) summary
    cl17173
    Location:21213
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    87151073..87165537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)