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Itgb3bp integrin beta 3 binding protein (beta3-endonexin) [ Mus musculus (house mouse) ]

Gene ID: 67733, updated on 26-Sep-2022

Summary

Official Symbol
Itgb3bpprovided by MGI
Official Full Name
integrin beta 3 binding protein (beta3-endonexin)provided by MGI
Primary source
MGI:MGI:1914983
See related
Ensembl:ENSMUSG00000028549 AllianceGenome:MGI:1914983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CENP-R; 4930471O16Rik
Summary
Predicted to be involved in CENP-A containing chromatin assembly and regulation of transcription, DNA-templated. Predicted to act upstream of or within apoptotic process and cell division. Predicted to be located in kinetochore and nucleus. Predicted to be active in nucleoplasm. Is expressed in brain; ovary; seminiferous tubule; spermatocyte; and spermatogonium. Orthologous to human ITGB3BP (integrin subunit beta 3 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 2.2), CNS E11.5 (RPKM 1.9) and 22 other tissues See more
Orthologs
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Genomic context

See Itgb3bp in Genome Data Viewer
Location:
4; 4 C6
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99655643..99717403, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99767406..99829215, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene forkhead box D3 Neighboring gene asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase) Neighboring gene EF-hand calcium binding domain 7 Neighboring gene predicted gene, 26425 Neighboring gene phosphoglucomutase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centromere protein R
Names
nuclear receptor-interacting factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362974.1NP_001349903.1  centromere protein R isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK165072
    Conserved Domains (1) summary
    pfam06729
    Location:885
    CENP-R; Kinetochore component, CENP-R
  2. NM_001362975.1NP_001349904.1  centromere protein R isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX005053, BX324127
    Conserved Domains (1) summary
    pfam06729
    Location:884
    CENP-R; Kinetochore component, CENP-R
  3. NM_001362976.1NP_001349905.1  centromere protein R isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX005053, BX324127
    Related
    ENSMUST00000102786.11
    Conserved Domains (1) summary
    pfam06729
    Location:177
    CENP-R; Kinetochore component, CENP-R
  4. NM_026348.4NP_080624.1  centromere protein R isoform 1

    See identical proteins and their annotated locations for NP_080624.1

    Status: VALIDATED

    Source sequence(s)
    AK045037, AK165072
    Consensus CDS
    CCDS18387.1
    UniProtKB/Swiss-Prot
    Q3TNR4, Q9CQ82
    Related
    ENSMUSP00000117153.2, ENSMUST00000146258.2
    Conserved Domains (1) summary
    pfam06729
    Location:25161
    CENP-R; Kinetochore component, CENP-R

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    99655643..99717403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240600.4XP_011238902.1  centromere protein R isoform X1

    Conserved Domains (1) summary
    pfam06729
    Location:27162
    CENP-R; Kinetochore component, CENP-R