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Fcrl6 Fc receptor-like 6 [ Mus musculus (house mouse) ]

Gene ID: 677296, updated on 19-Nov-2025
Official Symbol
Fcrl6provided by MGI
Official Full Name
Fc receptor-like 6provided by MGI
Primary source
MGI:MGI:3618339
See related
Ensembl:ENSMUSG00000070504 AllianceGenome:MGI:3618339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FcRH6; mIFGP6; moFcRH6
Summary
Enables protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Located in external side of plasma membrane. Is expressed in testis and thyroid gland. Orthologous to human FCRL6 (Fc receptor like 6). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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See Fcrl6 in Genome Data Viewer
Location:
1 H3; 1 80.0 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172423081..172445889, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172595514..172618322, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 8 Neighboring gene SLAM family member 8 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174563024-174563325 Neighboring gene dual specificity phosphatase 23 Neighboring gene predicted gene, 35601 Neighboring gene STARR-seq mESC enhancer starr_03070

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection. Honjo K, et al. Front Immunol, 2020. PMID 32117244, Free PMC Article
  2. Species-specific evolution of the FcR family in endothermic vertebrates. Fayngerts SA, et al. Immunogenetics, 2007 Jun. PMID 17356879
  3. New nomenclature for Fc receptor-like molecules. Maltais LJ, et al. Nat Immunol, 2006 May. PMID 16622424
  4. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Wilson TJ, et al. Blood, 2007 May 1. PMID 17213291
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.
    Title: Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
Fc receptor-like protein 6
Names
cell surface glycoprotein gp42
fcR-like protein 6

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164725.1 → NP_001158197.1  Fc receptor-like protein 6 precursor

    See identical proteins and their annotated locations for NP_001158197.1

    Status: VALIDATED

    Source sequence(s)
    AC131177
    Consensus CDS
    CCDS48448.1
    UniProtKB/Swiss-Prot
    A1YIY0, E9QM04
    Related
    ENSMUSP00000091861.5, ENSMUST00000094303.6
    Conserved Domains (2) summary
    pfam13895
    Location:22 → 106
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:114 → 187
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172423081..172445889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496971.3 → XP_006497034.1  Fc receptor-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006497034.1

    Conserved Domains (2) summary
    pfam13895
    Location:22 → 100
    Ig_2; Immunoglobulin domain
    pfam17736
    Location:128 → 196
    Ig_C17orf99; C17orf99 Ig domain

  2. XM_011238861.2 → XP_011237163.1  Fc receptor-like protein 6 isoform X2

    Conserved Domains (2) summary
    pfam13895
    Location:50 → 133
    Ig_2; Immunoglobulin domain
    pfam17736
    Location:161 → 229
    Ig_C17orf99; C17orf99 Ig domain

  3. XM_011238860.2 → XP_011237162.1  Fc receptor-like protein 6 isoform X1

    Conserved Domains (2) summary
    pfam13895
    Location:50 → 133
    Ig_2; Immunoglobulin domain
    pfam17736
    Location:161 → 229
    Ig_C17orf99; C17orf99 Ig domain

  4. XM_006496972.3 → XP_006497035.1  Fc receptor-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006497035.1

    Conserved Domains (2) summary
    pfam13895
    Location:22 → 100
    Ig_2; Immunoglobulin domain
    pfam17736
    Location:128 → 196
    Ig_C17orf99; C17orf99 Ig domain

  5. XM_011238862.2 → XP_011237164.1  Fc receptor-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_011237164.1

    Conserved Domains (2) summary
    pfam13895
    Location:22 → 100
    Ig_2; Immunoglobulin domain
    pfam17736
    Location:128 → 196
    Ig_C17orf99; C17orf99 Ig domain

  6. XM_030242468.1 → XP_030098328.1  Fc receptor-like protein 6 isoform X4

    Conserved Domains (1) summary
    pfam13895
    Location:50 → 133
    Ig_2; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1YIY0.2 GenPept UniProtKB/Swiss-Prot:A1YIY0

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