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STAC SH3 and cysteine rich domain [ Homo sapiens (human) ]

Gene ID: 6769, updated on 12-Aug-2022

Summary

Official Symbol
STACprovided by HGNC
Official Full Name
SH3 and cysteine rich domainprovided by HGNC
Primary source
HGNC:HGNC:11353
See related
Ensembl:ENSG00000144681 MIM:602317; AllianceGenome:HGNC:11353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAC1
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in prostate (RPKM 5.7), lung (RPKM 4.4) and 11 other tissues See more
Orthologs
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Genomic context

See STAC in Genome Data Viewer
Location:
3p22.3-p22.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (36380504..36548007)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (36381995..36549211)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (36421996..36589499)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36a pseudogene 17 Neighboring gene replication factor C 3 pseudogene 1 Neighboring gene uncharacterized LOC124906227 Neighboring gene NBPF member 21, pseudogene Neighboring gene RN7SK pseudogene 227

Genomic regions, transcripts, and products

Bibliography

Phenotypes

EBI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
EBI GWAS Catalog
Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32331

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SH3 and cysteine-rich domain-containing protein
Names
SRC homology 3 and cysteine-rich domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292049.2NP_001278978.1  SH3 and cysteine-rich domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001278978.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two coding exons compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK299160, AW137199, BC020221, DC351652
    Consensus CDS
    CCDS77722.1
    UniProtKB/TrEMBL
    B4DR96, E9PEA7, Q8WUK8
    Related
    ENSP00000393713.2, ENST00000457375.6
    Conserved Domains (4) summary
    cd11833
    Location:228280
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    cd11834
    Location:287337
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    pfam16664
    Location:130176
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl00040
    Location:108128
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  2. NM_003149.3NP_003140.1  SH3 and cysteine-rich domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_003140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AW137199, BC020221, DC351652
    Consensus CDS
    CCDS2662.1
    UniProtKB/Swiss-Prot
    B2R8S8, Q99469
    UniProtKB/TrEMBL
    Q8WUK8
    Related
    ENSP00000273183.3, ENST00000273183.8
    Conserved Domains (4) summary
    cd11833
    Location:289341
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    cd11834
    Location:348398
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    cd00029
    Location:108159
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam16664
    Location:166237
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    36380504..36548007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448767.1XP_047304723.1  SH3 and cysteine-rich domain-containing protein isoform X1

  2. XM_011534037.4XP_011532339.1  SH3 and cysteine-rich domain-containing protein isoform X2

    Conserved Domains (4) summary
    cd11833
    Location:278330
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    cd11834
    Location:337387
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    cd00029
    Location:97148
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam16664
    Location:155261
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
  3. XM_047448768.1XP_047304724.1  SH3 and cysteine-rich domain-containing protein isoform X3

  4. XM_047448770.1XP_047304726.1  SH3 and cysteine-rich domain-containing protein isoform X5

  5. XM_047448769.1XP_047304725.1  SH3 and cysteine-rich domain-containing protein isoform X4

    UniProtKB/TrEMBL
    B4DZ13
  6. XM_017007083.2XP_016862572.1  SH3 and cysteine-rich domain-containing protein isoform X4

    UniProtKB/TrEMBL
    B4DZ13
    Conserved Domains (4) summary
    cd11833
    Location:221273
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    cd00029
    Location:4091
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam16664
    Location:98204
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl17036
    Location:280330
    SH3; Src Homology 3 domain superfamily
  7. XM_047448771.1XP_047304727.1  SH3 and cysteine-rich domain-containing protein isoform X6

RNA

  1. XR_940496.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    36381995..36549211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)