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Rabl3 RAB, member RAS oncogene family-like 3 [ Mus musculus (house mouse) ]

Gene ID: 67657, updated on 9-May-2024

Summary

Official Symbol
Rabl3provided by MGI
Official Full Name
RAB, member RAS oncogene family-like 3provided by MGI
Primary source
MGI:MGI:1914907
See related
Ensembl:ENSMUSG00000022827 AllianceGenome:MGI:1914907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930553C05Rik
Summary
Enables GTP binding activity and protein homodimerization activity. Involved in lymphocyte differentiation and protein stabilization. Predicted to be active in endomembrane system. Is expressed in acoustic ganglion; otocyst; and urinary system. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RABL3 (RAB, member of RAS oncogene family like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.5), CNS E11.5 (RPKM 5.1) and 24 other tissues See more
Orthologs
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Genomic context

See Rabl3 in Genome Data Viewer
Location:
16 B3; 16 26.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37360220..37392747)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37539858..37572385)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 5-like Neighboring gene predicted gene, 57640 Neighboring gene STARR-seq mESC enhancer starr_40783 Neighboring gene STARR-positive B cell enhancer ABC_E2461 Neighboring gene general transcription factor II E, polypeptide 1 (alpha subunit) Neighboring gene predicted gene, 46559 Neighboring gene STARR-positive B cell enhancer ABC_E7447 Neighboring gene homogentisate 1, 2-dioxygenase Neighboring gene NADH:ubiquinone oxidoreductase subunit B4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein lipidation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
rab-like protein 3
Names
RAB, member of RAS oncogene family-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042499.1NP_001035964.1  rab-like protein 3

    See identical proteins and their annotated locations for NP_001035964.1

    Status: VALIDATED

    Source sequence(s)
    AC154762, AK016099
    Consensus CDS
    CCDS37338.1
    UniProtKB/Swiss-Prot
    Q8BMU2, Q9D0M6, Q9D4V7
    Related
    ENSMUSP00000023524.7, ENSMUST00000023524.13
    Conserved Domains (1) summary
    cd04102
    Location:7210
    RabL3; Rab GTPase-like family 3 (Rab-like3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    37360220..37392747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160101.1XP_036015994.1  rab-like protein 3 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:7154
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_384595.1 RNA Sequence

    Related
    ENSMUST00000130028.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026297.1: Suppressed sequence

    Description
    NM_026297.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.