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Akt1s1 AKT1 substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 67605, updated on 8-May-2024

Summary

Official Symbol
Akt1s1provided by MGI
Official Full Name
AKT1 substrate 1provided by MGI
Primary source
MGI:MGI:1914855
See related
Ensembl:ENSMUSG00000011096 AllianceGenome:MGI:1914855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lobe; Lobel; PRAS40; 1110012J22Rik
Summary
Involved in regulation of neuron apoptotic process. Located in cytosol. Is expressed in brain. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 52.6), ovary adult (RPKM 41.8) and 28 other tissues See more
Orthologs
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Genomic context

See Akt1s1 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44498648..44504845)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44849224..44855421)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62 Neighboring gene STARR-positive B cell enhancer ABC_E9111 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene microRNA 707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TORC1 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proline-rich AKT1 substrate 1
Names
AKT1 substrate 1 (proline-rich)
proline-rich AKT substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253920.1NP_001240849.1  proline-rich AKT1 substrate 1 isoform b

    See identical proteins and their annotated locations for NP_001240849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
    Source sequence(s)
    AK141771, BE847693, BY100800
    Consensus CDS
    CCDS21218.1
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Related
    ENSMUSP00000103512.2, ENSMUST00000107880.9
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  2. NM_001290694.1NP_001277623.1  proline-rich AKT1 substrate 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (a)
    Source sequence(s)
    AA015487, AK141771, BB618044, BE847693
    Consensus CDS
    CCDS71954.1
    UniProtKB/TrEMBL
    E9QKI5, F6R8S6
    Related
    ENSMUSP00000103514.2, ENSMUST00000107882.8
    Conserved Domains (1) summary
    pfam15798
    Location:154278
    PRAS; Proline-rich AKT1 substrate 1
  3. NM_001290695.1NP_001277624.1  proline-rich AKT1 substrate 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate first exon compared to variant 3. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AA231178, AK141771, BE847693, W71279
    UniProtKB/Swiss-Prot
    Q9D1F4
    Conserved Domains (1) summary
    pfam15798
    Location:27151
    PRAS; Proline-rich AKT1 substrate 1
  4. NM_001382480.1NP_001369409.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  5. NM_001382481.1NP_001369410.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  6. NM_001382482.1NP_001369411.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  7. NM_001382483.1NP_001369412.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  8. NM_001382484.1NP_001369413.1  proline-rich AKT1 substrate 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  9. NM_026270.4NP_080546.1  proline-rich AKT1 substrate 1 isoform b

    See identical proteins and their annotated locations for NP_080546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
    Source sequence(s)
    AK141771, BE847693, BY103589
    Consensus CDS
    CCDS21218.1
    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Related
    ENSMUSP00000049764.9, ENSMUST00000054343.15
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44498648..44504845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242937.2XP_030098797.1  proline-rich AKT1 substrate 1 isoform X2

    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Related
    ENSMUSP00000116149.3, ENSMUST00000127783.2
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1
  2. XM_006541117.3XP_006541180.1  proline-rich AKT1 substrate 1 isoform X1

    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:135259
    PRAS; Proline-rich AKT1 substrate 1
  3. XM_006541118.5XP_006541181.1  proline-rich AKT1 substrate 1 isoform X3

    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:131255
    PRAS; Proline-rich AKT1 substrate 1
  4. XM_036153382.1XP_036009275.1  proline-rich AKT1 substrate 1 isoform X2

    UniProtKB/Swiss-Prot
    A2RT52, Q9D1F4
    UniProtKB/TrEMBL
    F6R8S6
    Conserved Domains (1) summary
    pfam15798
    Location:128252
    PRAS; Proline-rich AKT1 substrate 1