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Get4 golgi to ER traffic protein 4 [ Mus musculus (house mouse) ]

Gene ID: 67604, updated on 30-Apr-2024

Summary

Official Symbol
Get4provided by MGI
Official Full Name
golgi to ER traffic protein 4provided by MGI
Primary source
MGI:MGI:1914854
See related
Ensembl:ENSMUSG00000025858 AllianceGenome:MGI:1914854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cee; 1110007L15Rik
Summary
Predicted to enable chaperone binding activity. Predicted to be involved in cytoplasmic sequestering of protein; maintenance of unfolded protein involved in ERAD pathway; and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in chromosome; cytoplasm; and nuclear lumen. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 65.6), adrenal adult (RPKM 60.9) and 28 other tissues See more
Orthologs
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Genomic context

See Get4 in Genome Data Viewer
Location:
5 G2; 5 78.23 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139237303..139255806)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139252324..139270050)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene STARR-positive B cell enhancer ABC_E1695 Neighboring gene STARR-seq mESC enhancer starr_14685 Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E10360 Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4802 Neighboring gene STARR-positive B cell enhancer ABC_E2770 Neighboring gene STARR-positive B cell enhancer ABC_E6389 Neighboring gene STARR-positive B cell enhancer ABC_E9266 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E8825 Neighboring gene STARR-positive B cell enhancer ABC_E6390 Neighboring gene cytochrome c oxidase assembly protein 19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BAT3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BAT3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Golgi to ER traffic protein 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163316.1NP_001156788.1  Golgi to ER traffic protein 4 homolog isoform 2

    See identical proteins and their annotated locations for NP_001156788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK003551, CJ048159
    Consensus CDS
    CCDS51682.1
    UniProtKB/Swiss-Prot
    Q9D1H7
    Related
    ENSMUSP00000106502.2, ENSMUST00000110878.2
    Conserved Domains (1) summary
    pfam04190
    Location:3237
    DUF410; Protein of unknown function (DUF410)
  2. NM_001359238.1NP_001346167.1  Golgi to ER traffic protein 4 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to variant 1.
    Source sequence(s)
    AC125065
    Conserved Domains (1) summary
    pfam04190
    Location:56291
    DUF410; Protein of unknown function (DUF410)
  3. NM_026269.2NP_080545.2  Golgi to ER traffic protein 4 homolog isoform 1

    See identical proteins and their annotated locations for NP_080545.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK003551, CJ053487
    Consensus CDS
    CCDS19805.1
    UniProtKB/Swiss-Prot
    Q78J86, Q9D1H7
    Related
    ENSMUSP00000026976.6, ENSMUST00000026976.12
    Conserved Domains (1) summary
    pfam04190
    Location:56292
    DUF410; Protein of unknown function (DUF410)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139237303..139255806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165440.1XP_036021333.1  Golgi to ER traffic protein 4 homolog isoform X1

    Conserved Domains (1) summary
    pfam04190
    Location:7145
    DUF410; Protein of unknown function (DUF410)
  2. XM_036165441.1XP_036021334.1  Golgi to ER traffic protein 4 homolog isoform X1

    Conserved Domains (1) summary
    pfam04190
    Location:7145
    DUF410; Protein of unknown function (DUF410)

RNA

  1. XR_004942553.1 RNA Sequence