Tespa1 thymocyte expressed, positive selection associated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tespa1provided by MGI
Official Full Name: thymocyte expressed, positive selection associated 1provided by MGI
Primary source: MGI:MGI:1914846
See related: Ensembl:ENSMUSG00000034833 AllianceGenome:MGI:1914846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Itprid3; 5830405N20Rik; A430001F24Rik
Summary: Enables phospholipase binding activity. Involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within TCR signalosome assembly. Located in cytoplasm. Part of TCR signalosome. Is expressed in testis; thymus; and thymus primordium. Orthologous to human TESPA1 (thymocyte expressed, positive selection associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 15.0), spleen adult (RPKM 3.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10; 10 D3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (130158696..130199338)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (130322826..130363469)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
Title: Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
Thymic-specific regulation of TCR signaling by Tespa1.
Title: Thymic-specific regulation of TCR signaling by Tespa1.
Our study demonstrates that Tespa1 is essential for T cell-dependent B cell responses, and suggests an important role for Tespa1 during the development of autoimmune arthritis.
Title: Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice.
Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1
Title: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI.
Title: Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
Tespa1 is post-translationally modified upon intracellular Ca2+ increase in thymocytes.
Title: Tespa1 protein is phosphorylated in response to store-operated calcium entry.
Tespa1 is a component of the TCR signalosome and is essential for T-cell selection and maturation through regulation of TCR signaling during T-cell development.
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Homology

Homologs of the Tespa1 gene: The Tespa1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and frog.
Orthologs from Annotation Pipeline: 424 organisms have orthologs with human gene Tespa1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in COP9 signalosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell differentiation in thymus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within TCR signalosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
part_of TCR signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of TCR signalosome	IMP Inferred from Mutant Phenotype more info	PubMed
part_of TCR signalosome	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein TESPA1

Names: thymocyte-expressed positive selection-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.