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Tctn3 tectonic family member 3 [ Mus musculus (house mouse) ]

Gene ID: 67590, updated on 26-Sep-2022

Summary

Official Symbol
Tctn3provided by MGI
Official Full Name
tectonic family member 3provided by MGI
Primary source
MGI:MGI:1914840
See related
Ensembl:ENSMUSG00000025008 AllianceGenome:MGI:1914840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tect3; 4930521E07Rik
Summary
Involved in cilium assembly. Predicted to be located in nucleus. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in Joubert syndrome 18 and orofaciodigital syndrome IV. Orthologous to human TCTN3 (tectonic family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 7.9), testis adult (RPKM 7.3) and 27 other tissues See more
Orthologs
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Genomic context

See Tctn3 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40584890..40600768, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40596446..40612324, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 18 family, member A1 Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene predicted gene, 27042 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene protein tyrosine phosphatase 4a1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365072.1NP_001352001.1  tectonic-3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK030156, AW491485, DQ278871
    Consensus CDS
    CCDS89390.1
    UniProtKB/TrEMBL
    A0A0R4J1W4
    Related
    ENSMUSP00000121760.2, ENSMUST00000132452.2
    Conserved Domains (1) summary
    pfam07773
    Location:78354
    DUF1619; Protein of unknown function (DUF1619)
  2. NM_026260.3NP_080536.2  tectonic-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080536.2

    Status: VALIDATED

    Source sequence(s)
    AC142101, AC166063
    Consensus CDS
    CCDS29804.1
    UniProtKB/Swiss-Prot
    Q8R2Q6, Q9CRC5
    Related
    ENSMUSP00000025981.9, ENSMUST00000025981.15
    Conserved Domains (1) summary
    pfam07773
    Location:78379
    DUF1619; Protein of unknown function (DUF1619)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    40584890..40600768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251056.2XP_030106916.1  tectonic-3 isoform X1

    Conserved Domains (1) summary
    pfam07773
    Location:1596
    DUF1619; Protein of unknown function (DUF1619)

RNA

  1. XR_004940172.1 RNA Sequence

  2. XR_001782613.3 RNA Sequence

  3. XR_386503.2 RNA Sequence