Format

Send to:

Choose Destination

SSX1 SSX family member 1 [ Homo sapiens (human) ]

Gene ID: 6756, updated on 11-Jun-2021

Summary

Official Symbol
SSX1provided by HGNC
Official Full Name
SSX family member 1provided by HGNC
Primary source
HGNC:HGNC:11335
See related
Ensembl:ENSG00000126752 MIM:312820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSRC; CT5.1
Summary
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]
Expression
Restricted expression toward testis (RPKM 3.9) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SSX1 in Genome Data Viewer
Location:
Xp11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48255392..48267444)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48114827..48126879)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene S100A11 pseudogene 7 Neighboring gene ornithine aminotransferase pseudogene Neighboring gene S100A11 pseudogene 6 Neighboring gene SSX family member 5 pseudogene Neighboring gene SSX family pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5162, MGC150425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein SSX1
Names
cancer/testis antigen 5.1
cancer/testis antigen family 5, member 1
sarcoma, synovial, X-chromosome-related 1
synovial sarcoma, X breakpoint 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012528.2 RefSeqGene

    Range
    5031..17083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278691.2NP_001265620.1  protein SSX1

    See identical proteins and their annotated locations for NP_001265620.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC245047, BC150487, BE777476, BF211314, BQ774004
    Consensus CDS
    CCDS14290.1
    UniProtKB/Swiss-Prot
    Q16384
    Conserved Domains (2) summary
    smart00349
    Location:2382
    KRAB; krueppel associated box
    pfam09514
    Location:156187
    SSXRD; SSXRD motif
  2. NM_005635.4NP_005626.1  protein SSX1

    See identical proteins and their annotated locations for NP_005626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC150487, BQ774004
    Consensus CDS
    CCDS14290.1
    UniProtKB/Swiss-Prot
    Q16384
    Related
    ENSP00000366118.3, ENST00000376919.4
    Conserved Domains (2) summary
    smart00349
    Location:2382
    KRAB; krueppel associated box
    pfam09514
    Location:156187
    SSXRD; SSXRD motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48255392..48267444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center