Mgat4d MGAT4 family, member C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mgat4dprovided by MGI
Official Full Name: MGAT4 family, member Cprovided by MGI
Primary source: MGI:MGI:1914805
See related: Ensembl:ENSMUSG00000035057 AllianceGenome:MGI:1914805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GnT1IP; GnT1IP-L; 4933434I20Rik
Summary: Predicted to enable acetylglucosaminyltransferase activity. Involved in negative regulation of protein glycosylation. Located in several cellular components, including Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4D (MGAT4 family member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 6.4) See more
Orthologs: human all
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Genomic context

Location:: 8; 8 C2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84075101..84106031)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (83348472..83379402)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Homology

Homologs of the Mgat4d gene: The Mgat4d gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 317 organisms have orthologs with human gene Mgat4d
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi stack	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D

Names: GlcNAcT-I inhibitory protein; N-acetylglucosaminyltransferase MGAT1 inhibitory protein; glycosyltransferase 54 domain-containing protein

NP_080509.2

EC 2.4.1.-

XP_017168435.1

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026233.2 → NP_080509.2 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D

See identical proteins and their annotated locations for NP_080509.2

Status: VALIDATED

Source sequence(s)

AC155304, AK016272

Consensus CDS

CCDS22451.1

UniProtKB/Swiss-Prot

E9QM08, Q9D4R2

Related

ENSMUSP00000041629.6, ENSMUST00000038692.6

Conserved Domains (1) summary

pfam04666
Location:96 → 373

Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

84075101..84106031

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312946.1 → XP_017168435.1 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X1

Conserved Domains (1) summary

pfam04666
Location:185 → 462

Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region