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Mgat4d MGAT4 family, member C [ Mus musculus (house mouse) ]

Gene ID: 67555, updated on 24-Sep-2025
Official Symbol
Mgat4dprovided by MGI
Official Full Name
MGAT4 family, member Cprovided by MGI
Primary source
MGI:MGI:1914805
See related
Ensembl:ENSMUSG00000035057 AllianceGenome:MGI:1914805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GnT1IP; GnT1IP-L; 4933434I20Rik
Summary
Predicted to enable acetylglucosaminyltransferase activity. Involved in negative regulation of protein glycosylation. Located in several cellular components, including Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4D (MGAT4 family member D). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward testis adult (RPKM 6.4) See more
Orthologs
human all
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See Mgat4d in Genome Data Viewer
Location:
8 C2; 8 39.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84075101..84106031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83348472..83379402)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22080 Neighboring gene ELMO/CED-12 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1762 Neighboring gene predicted gene, 32327 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_22081 Neighboring gene predicted gene, 32377 Neighboring gene calmegin

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of Testicular Germ Cells From Mild Heat Stress. Akintayo A, et al. Sci Rep, 2020 Feb 7. PMID 32034218, Free PMC Article
  2. A testis-specific regulator of complex and hybrid N-glycan synthesis. Huang HH, et al. J Cell Biol, 2010 Sep 6. PMID 20805325, Free PMC Article
  3. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
Names
GlcNAcT-I inhibitory protein
N-acetylglucosaminyltransferase MGAT1 inhibitory protein
glycosyltransferase 54 domain-containing protein
NP_080509.2
XP_017168435.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026233.2 → NP_080509.2  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor

    See identical proteins and their annotated locations for NP_080509.2

    Status: VALIDATED

    Source sequence(s)
    AC155304, AK016272
    Consensus CDS
    CCDS22451.1
    UniProtKB/Swiss-Prot
    E2F697, E9QM08, Q9D4R2
    Related
    ENSMUSP00000041629.6, ENSMUST00000038692.6
    Conserved Domains (1) summary
    pfam04666
    Location:96 → 373
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84075101..84106031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312946.1 → XP_017168435.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X1

    Conserved Domains (1) summary
    pfam04666
    Location:185 → 462
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4R2.2 GenPept UniProtKB/Swiss-Prot:Q9D4R2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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