Format

Send to:

Choose Destination

SSTR5 somatostatin receptor 5 [ Homo sapiens (human) ]

Gene ID: 6755, updated on 18-Aug-2020

Summary

Official Symbol
SSTR5provided by HGNC
Official Full Name
somatostatin receptor 5provided by HGNC
Primary source
HGNC:HGNC:11334
See related
Ensembl:ENSG00000162009 MIM:182455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SS-5-R
Summary
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SSTR5 in Genome Data Viewer
Location:
16p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1072756..1081454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1122756..1131454)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984898 Neighboring gene SRY-box transcription factor 8 Neighboring gene SSTR5 antisense RNA 1 Neighboring gene C1q and TNF related 8 Neighboring gene uncharacterized LOC107984906

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
somatostatin receptor type 5
Names
somatostatin receptor subtype 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016744.1 RefSeqGene

    Range
    5001..13699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001053.4NP_001044.1  somatostatin receptor type 5

    See identical proteins and their annotated locations for NP_001044.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009041
    Consensus CDS
    CCDS10429.1
    UniProtKB/Swiss-Prot
    P35346
    Related
    ENSP00000293897.4, ENST00000293897.5
    Conserved Domains (2) summary
    pfam00001
    Location:57304
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54319
    7tm_4; Olfactory receptor
  2. NM_001172560.1NP_001166031.1  somatostatin receptor type 5

    See identical proteins and their annotated locations for NP_001166031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009041
    Consensus CDS
    CCDS10429.1
    UniProtKB/Swiss-Prot
    P35346
    Conserved Domains (2) summary
    pfam00001
    Location:57304
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54319
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1072756..1081454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001172572.1: Suppressed sequence

    Description
    NM_001172572.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and it aligns with non-consensus splice sites.
  2. NM_001172573.1: Suppressed sequence

    Description
    NM_001172573.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and it aligns with non-consensus splice sites.
Support Center