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Nudt7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 [ Mus musculus (house mouse) ]

Gene ID: 67528, updated on 19-Apr-2019

Summary

Official Symbol
Nudt7provided by MGI
Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 7provided by MGI
Primary source
MGI:MGI:1914778
See related
Ensembl:ENSMUSG00000031767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300007B24Rik; 2210404C19Rik
Expression
Biased expression in liver adult (RPKM 27.8), subcutaneous fat pad adult (RPKM 6.0) and 7 other tissues See more
Orthologs

Genomic context

See Nudt7 in Genome Data Viewer
Location:
8; 8 E1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (114133574..114154731)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (116657479..116676205)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 Neighboring gene predicted gene, 30107 Neighboring gene predicted gene, 30272 Neighboring gene vesicle amine transport protein 1 like Neighboring gene RIKEN cDNA 4933408N05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
acetyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 
NOT m7G(5')pppN diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acetyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
coenzyme A catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coenzyme A catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside diphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal coenzyme A diphosphatase NUDT7
Names
coenzyme A diphosphatase
nucleoside diphosphate-linked moiety X motif 7
nudix motif 7
NP_001277109.1
NP_001277110.1
NP_001277111.1
NP_077757.2
NP_077766.3
XP_011246793.1
XP_017168434.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290180.1NP_001277109.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 3

    See identical proteins and their annotated locations for NP_001277109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, resulting in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924
    Consensus CDS
    CCDS80933.1
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000065791.6, ENSMUST00000066514.12
    Conserved Domains (1) summary
    cd03426
    Location:32172
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  2. NM_001290181.1NP_001277110.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 4

    See identical proteins and their annotated locations for NP_001277110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924
    Consensus CDS
    CCDS80935.1
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000104737.1, ENSMUST00000109109.7
    Conserved Domains (1) summary
    cd03426
    Location:65225
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  3. NM_001290182.1NP_001277111.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a 3' exon but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC121999, AK008824, BC033046
    Consensus CDS
    CCDS80934.1
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000116868.1, ENSMUST00000134593.1
    Conserved Domains (1) summary
    cd03426
    Location:41121
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  4. NM_024437.4NP_077757.2  peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

    See identical proteins and their annotated locations for NP_077757.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924
    Consensus CDS
    CCDS22687.1
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000073213.5, ENSMUST00000073521.11
    Conserved Domains (1) summary
    cd03426
    Location:41201
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  5. NM_024446.5NP_077766.3  peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

    See identical proteins and their annotated locations for NP_077766.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924, AK011172
    Consensus CDS
    CCDS22688.2
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000114598.1, ENSMUST00000147605.7
    Conserved Domains (1) summary
    cd03426
    Location:41181
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    114133574..114154731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312945.1XP_017168434.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X1

  2. XM_011248491.1XP_011246793.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X2

    Conserved Domains (1) summary
    cd03426
    Location:65138
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
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