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Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 67512, updated on 11-Jun-2025
Official Symbol
Agpat2provided by MGI
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 2provided by MGI
Primary source
MGI:MGI:1914762
See related
Ensembl:ENSMUSG00000026922 AllianceGenome:MGI:1914762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSCL; BSCL1; LPAAB; 1-AGPAT 2; LPAAT-beta; 2510002J07Rik
Summary
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in triglyceride biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and urinary system. Used to study congenital generalized lipodystrophy type 1. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 450.2), mammary gland adult (RPKM 425.2) and 15 other tissues See more
Orthologs
human all
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See Agpat2 in Genome Data Viewer
Location:
2 A3; 2 18.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26483069..26494429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26593057..26604417, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03986 Neighboring gene predicted gene, 36171 Neighboring gene EGF-like domain 7 Neighboring gene microRNA 126a Neighboring gene microRNA 126b Neighboring gene STARR-seq mESC enhancer starr_03989 Neighboring gene predicted gene, 39772 Neighboring gene divergent protein kinase domain 1B

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction. Agarwal AK, et al. iScience, 2024 Jan 19. PMID 38274405, Free PMC Article
  2. Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue. Agarwal AK, et al. iScience, 2023 Oct 20. PMID 37752957, Free PMC Article
  3. Prevalence of mutations in AGPAT2 among human lipodystrophies. Magré J, et al. Diabetes, 2003 Jun. PMID 12765973
  4. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. Gale SE, et al. J Biol Chem, 2006 Apr 21. PMID 16495223
  5. Decreased caveolae in AGPAT2 lacking adipocytes is independent of changes in cholesterol or sphingolipid levels: A whole cell and plasma membrane lipidomic analysis of adipogenesis. González-Hódar L, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Sep 1. PMID 33989739

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr[-/-] mice.
    Title: Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr(-/-) mice.
  2. AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway.
    Title: AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway.
  3. Adipogenically induced Agpat2(-/-) preadipocytes had fewer lipid-loaded cells and lower levels of adipocyte markers than wild type preadipocytes.
    Title: AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism.
  4. Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors
    Title: Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
  5. The lack of normal insulin signaling in Agpat2(-/-) livers allows unrestricted phosphatidic acid-induced gluconeogenesis.
    Title: Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice.
  6. Data suggest that Agpat2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt and PPARgamma signaling in early stage of adipogenesis.
    Title: Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations.
  7. the role of AGPAT1 or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin resistance
    Title: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.
  8. Loss of adipocytes by necrosis and apoptosis in Agpat2 null mice
    Title: Pathology of congenital generalized lipodystrophy in Agpat2-/- mice.
  9. The alternative monoacylglycerol pathway for triglyceride biosynthesis is activated in the absence of 1-acylglycerol-3-phosphate O-acyltransferase 2.
    Title: Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.
  10. There is a prevalence of mutations in this enzymes among human lipodystrophies
    Title: Prevalence of mutations in AGPAT2 among human lipodystrophies.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Names
1-AGP acyltransferase 2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
NP_080488.1
XP_017174711.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026212.2 → NP_080488.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor

    See identical proteins and their annotated locations for NP_080488.1

    Status: VALIDATED

    Source sequence(s)
    AK002422, AL732311, BB871777, BC125530
    Consensus CDS
    CCDS15809.1
    UniProtKB/Swiss-Prot
    Q8K3K7
    UniProtKB/TrEMBL
    Q059U0
    Related
    ENSMUSP00000028286.6, ENSMUST00000028286.12
    Conserved Domains (2) summary
    cd07989
    Location:67 → 240
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:30 → 259
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26483069..26494429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319222.3 → XP_017174711.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1

    Related
    ENSMUST00000131940.8
    Conserved Domains (1) summary
    cd07989
    Location:4 → 137
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3K7.1 GenPept UniProtKB/Swiss-Prot:Q8K3K7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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