U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 67512, updated on 11-Jun-2025
Official Symbol
Agpat2provided by MGI
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 2provided by MGI
Primary source
MGI:MGI:1914762
See related
Ensembl:ENSMUSG00000026922 AllianceGenome:MGI:1914762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSCL; BSCL1; LPAAB; 1-AGPAT 2; LPAAT-beta; 2510002J07Rik
Summary
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in triglyceride biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and urinary system. Used to study congenital generalized lipodystrophy type 1. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 450.2), mammary gland adult (RPKM 425.2) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See Agpat2 in Genome Data Viewer
Location:
2 A3; 2 18.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26483069..26494429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26593057..26604417, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03986 Neighboring gene predicted gene, 36171 Neighboring gene EGF-like domain 7 Neighboring gene microRNA 126a Neighboring gene microRNA 126b Neighboring gene STARR-seq mESC enhancer starr_03989 Neighboring gene predicted gene, 39772 Neighboring gene divergent protein kinase domain 1B

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Names
1-AGP acyltransferase 2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
NP_080488.1
XP_017174711.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026212.2NP_080488.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor

    See identical proteins and their annotated locations for NP_080488.1

    Status: VALIDATED

    Source sequence(s)
    AK002422, AL732311, BB871777, BC125530
    Consensus CDS
    CCDS15809.1
    UniProtKB/Swiss-Prot
    Q8K3K7
    UniProtKB/TrEMBL
    Q059U0
    Related
    ENSMUSP00000028286.6, ENSMUST00000028286.12
    Conserved Domains (2) summary
    cd07989
    Location:67240
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:30259
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26483069..26494429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319222.3XP_017174711.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1

    Related
    ENSMUST00000131940.8
    Conserved Domains (1) summary
    cd07989
    Location:4137
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like