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SSRP1 structure specific recognition protein 1 [ Homo sapiens (human) ]

Gene ID: 6749, updated on 5-Sep-2021

Summary

Official Symbol
SSRP1provided by HGNC
Official Full Name
structure specific recognition protein 1provided by HGNC
Primary source
HGNC:HGNC:11327
See related
Ensembl:ENSG00000149136 MIM:604328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FACT; T160; FACT80
Summary
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 33.5), ovary (RPKM 32.7) and 25 other tissues See more
Orthologs
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Genomic context

See SSRP1 in Genome Data Viewer
Location:
11q12.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57325986..57335892, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57093462..57103366, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984364 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene purinergic receptor P2X 3 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection requires SSRP1 as shown through shRNA-mediated knockdown of SSRP1 in human CD4+ T cells PubMed
shRNA knockdown of SSRP1 increases HIV-1 LTR-driven gene expression in HEK293 cells transduced with VSV-G pseudo-typed HIV-1 NL4-3-Luc construct; i.e. HIV-1 is restricted by SSRP1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The heterodimeric complex FACT proteins SPT16 and SSRP1 are recognized to interact with HIV-1 in Jurkat cell PubMed
tat HIV-1 Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and that the FACT complex, at least consisting of SPT16 and SSRP1, may be responsible for their removal PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of chromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
FACT complex subunit SSRP1
Names
FACT 80 kDa subunit
FACTp80
chromatin-specific transcription elongation factor 80 kDa subunit
cisplatin-DNA SSRP
facilitates chromatin remodeling 80 kDa subunit
facilitates chromatin transcription complex 80 kDa subunit
facilitates chromatin transcription complex subunit SSRP1
hSSRP1
high mobility group box
recombination signal sequence recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003146.3NP_003137.1  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_003137.1

    Status: REVIEWED

    Source sequence(s)
    AP000781
    Consensus CDS
    CCDS7952.1
    UniProtKB/Swiss-Prot
    Q08945
    UniProtKB/TrEMBL
    A0A024R4Z6
    Related
    ENSP00000278412.2, ENST00000278412.7
    Conserved Domains (2) summary
    COG5165
    Location:21480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:547614
    HMG_box; HMG (high mobility group) box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57325986..57335892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448665.1XP_024304433.1  FACT complex subunit SSRP1 isoform X3

    Conserved Domains (3) summary
    COG5165
    Location:21575
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:642709
    HMG_box; HMG (high mobility group) box
    pfam03531
    Location:75379
    SSrecog; Structure-specific recognition protein (SSRP1)
  2. XM_024448666.1XP_024304434.1  FACT complex subunit SSRP1 isoform X3

    Conserved Domains (3) summary
    COG5165
    Location:21575
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:642709
    HMG_box; HMG (high mobility group) box
    pfam03531
    Location:75379
    SSrecog; Structure-specific recognition protein (SSRP1)
  3. XM_017018180.1XP_016873669.1  FACT complex subunit SSRP1 isoform X2

  4. XM_024448664.1XP_024304432.1  FACT complex subunit SSRP1 isoform X1

    Conserved Domains (3) summary
    COG5165
    Location:155709
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:776843
    HMG_box; HMG (high mobility group) box
    pfam03531
    Location:209513
    SSrecog; Structure-specific recognition protein (SSRP1)
  5. XM_024448667.1XP_024304435.1  FACT complex subunit SSRP1 isoform X4

    Conserved Domains (2) summary
    cd13231
    Location:561656
    PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
    pfam03531
    Location:209513
    SSrecog; Structure-specific recognition protein (SSRP1)
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