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Calcoco1 calcium binding and coiled coil domain 1 [ Mus musculus (house mouse) ]

Gene ID: 67488, updated on 12-May-2024

Summary

Official Symbol
Calcoco1provided by MGI
Official Full Name
calcium binding and coiled coil domain 1provided by MGI
Primary source
MGI:MGI:1914738
See related
Ensembl:ENSMUSG00000023055 AllianceGenome:MGI:1914738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cocoa; Gcap11; mKIAA1536; 1810009B06Rik
Summary
Enables chromatin binding activity and transcription coactivator activity. Involved in intracellular steroid hormone receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in chromatin. Is expressed in embryo and thymus primordium. Orthologous to human CALCOCO1 (calcium binding and coiled-coil domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 33.2), heart adult (RPKM 30.0) and 28 other tissues See more
Orthologs
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Genomic context

See Calcoco1 in Genome Data Viewer
Location:
15 F3; 15 57.81 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102615212..102630616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102706777..102722178, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2 Neighboring gene STARR-seq mESC enhancer starr_39853 Neighboring gene microRNA 688 Neighboring gene STARR-seq mESC enhancer starr_39855 Neighboring gene STARR-positive B cell enhancer ABC_E2453 Neighboring gene predicted gene, 36510 Neighboring gene STARR-positive B cell enhancer ABC_E7424 Neighboring gene predicted gene, 36560 Neighboring gene chondrogenesis associated transcript

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • KIAA1536

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium-binding and coiled-coil domain-containing protein 1
Names
GRIP1-interacting protein
coiled-coil coactivator protein
coiled-coil transcriptional coactivator
granule cell antiserum positive 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026192.3NP_080468.1  calcium-binding and coiled-coil domain-containing protein 1

    See identical proteins and their annotated locations for NP_080468.1

    Status: VALIDATED

    Source sequence(s)
    AC123870, AC124532, AK035598, BC054783
    Consensus CDS
    CCDS27889.1
    UniProtKB/Swiss-Prot
    Q5DTX0, Q8CGU1, Q9D935
    UniProtKB/TrEMBL
    E9Q7U2
    Related
    ENSMUSP00000023818.4, ENSMUST00000023818.11
    Conserved Domains (2) summary
    pfam07888
    Location:13584
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    cl23720
    Location:420510
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102615212..102630616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159550.1XP_036015443.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    E9Q7U2
    Related
    ENSMUSP00000130170.2, ENSMUST00000171838.2
    Conserved Domains (2) summary
    pfam07888
    Location:122584
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:15118
    SKICH; SKICH domain