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Dhx40 DEAH-box helicase 40 [ Mus musculus (house mouse) ]

Gene ID: 67487, updated on 7-Aug-2026
Official Symbol
Dhx40provided by MGI
Official Full Name
DEAH-box helicase 40provided by MGI
Primary source
MGI:MGI:1914737
See related
Ensembl:ENSMUSG00000018425 AllianceGenome:MGI:1914737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAD; DDX40; ARG147; 2410016C14Rik
Summary
Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in several structures, including adrenal gland; brain; gut; skeletal muscle tissue; and trigeminal nerve. Orthologous to human DHX40 (DEAH-box helicase 40). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 11.1), testis adult (RPKM 10.7) and 25 other tissues See more
Orthologs
all
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See Dhx40 in Genome Data Viewer
Location:
11 C; 11 51.82 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86659675..86698695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86768849..86807877, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30275 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene clathrin heavy chain Neighboring gene STARR-positive B cell enhancer ABC_E3989 Neighboring gene STARR-positive B cell enhancer ABC_E7036 Neighboring gene STARR-seq mESC enhancer starr_30277 Neighboring gene predicted gene, 42085 Neighboring gene STARR-seq mESC enhancer starr_30279 Neighboring gene STARR-positive B cell enhancer ABC_E7037 Neighboring gene predicted gene, 33742 Neighboring gene STARR-seq mESC enhancer starr_30281 Neighboring gene microRNA 12182 Neighboring gene predicted gene, 38942

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells. Al Adhami H, et al. Nucleic Acids Res, 2023 Apr 24. PMID 36772830, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
probable ATP-dependent RNA helicase DHX40
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 40
DEAH box protein 40
NP_080467.3
XP_017170207.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026191.2 → NP_080467.3  probable ATP-dependent RNA helicase DHX40

    See identical proteins and their annotated locations for NP_080467.3

    Status: VALIDATED

    Source sequence(s)
    AK010512, BP771378, BY329362, CF749423
    Consensus CDS
    CCDS36268.1
    UniProtKB/Swiss-Prot
    Q6PE54, Q8BPH2, Q8CD88, Q9CWN3
    Related
    ENSMUSP00000018569.7, ENSMUST00000018569.15
    Conserved Domains (5) summary
    smart00490
    Location:312 → 399
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:48 → 236
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:469 → 557
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:78 → 213
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:591 → 699
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86659675..86698695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314718.3 → XP_017170207.1  probable ATP-dependent RNA helicase DHX40 isoform X1

    Related
    ENSMUSP00000324774.1, ENSMUST00000546411.1
    Conserved Domains (1) summary
    COG1643
    Location:125 → 636
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PE54.1 GenPept UniProtKB/Swiss-Prot:Q6PE54

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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