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Pdcl phosducin-like [ Mus musculus (house mouse) ]

Gene ID: 67466, updated on 9-May-2024

Summary

Official Symbol
Pdclprovided by MGI
Official Full Name
phosducin-likeprovided by MGI
Primary source
MGI:MGI:1914716
See related
Ensembl:ENSMUSG00000009030 AllianceGenome:MGI:1914716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PhLP1; 1200011E13Rik
Summary
Involved in positive regulation of smoothened signaling pathway. Acts upstream of or within heterotrimeric G-protein complex assembly and visual perception. Predicted to be located in cytoplasm. Orthologous to human PDCL (phosducin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.6), CNS E14 (RPKM 11.9) and 27 other tissues See more
Orthologs
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Genomic context

See Pdcl in Genome Data Viewer
Location:
2 B; 2 24.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37240086..37249832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37350074..37359820, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22306 Neighboring gene STARR-seq mESC enhancer starr_04311 Neighboring gene olfactory receptor family 5 subfamily C member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4441 Neighboring gene STARR-seq mESC enhancer starr_04312 Neighboring gene STARR-positive B cell enhancer ABC_E7813 Neighboring gene ring finger and CCCH-type zinc finger domains 2 Neighboring gene STARR-seq mESC enhancer starr_04313 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene STARR-positive B cell enhancer ABC_E1244 Neighboring gene STARR-positive B cell enhancer ABC_E11130 Neighboring gene STARR-positive B cell enhancer ABC_E4442 Neighboring gene zinc finger and BTB domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosducin-like protein
Names
PHLP
NP_080452.2
XP_006498315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026176.3NP_080452.2  phosducin-like protein

    See identical proteins and their annotated locations for NP_080452.2

    Status: VALIDATED

    Source sequence(s)
    AK028668, AV286628, BY024444
    Consensus CDS
    CCDS15998.1
    UniProtKB/Swiss-Prot
    Q3TKI0, Q9DBX2
    UniProtKB/TrEMBL
    Q3UZN6
    Related
    ENSMUSP00000009174.9, ENSMUST00000009174.15
    Conserved Domains (1) summary
    pfam02114
    Location:35299
    Phosducin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    37240086..37249832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498252.1XP_006498315.1  phosducin-like protein isoform X1

    See identical proteins and their annotated locations for XP_006498315.1

    UniProtKB/Swiss-Prot
    Q3TKI0, Q9DBX2
    UniProtKB/TrEMBL
    Q3UZN6
    Conserved Domains (1) summary
    pfam02114
    Location:35299
    Phosducin