U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sf3a1 splicing factor 3a, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 67465, updated on 8-Feb-2024

Summary

Official Symbol
Sf3a1provided by MGI
Official Full Name
splicing factor 3a, subunit 1provided by MGI
Primary source
MGI:MGI:1914715
See related
Ensembl:ENSMUSG00000002129 AllianceGenome:MGI:1914715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200014H24Rik; 5930416L09Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to act upstream of or within RNA splicing. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human SF3A1 (splicing factor 3a subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.8), thymus adult (RPKM 22.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sf3a1 in Genome Data Viewer
Location:
11 A1; 11 2.91 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4110354..4132541)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4160354..4182541)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060 Neighboring gene coiled-coil domain containing 157 Neighboring gene STARR-positive B cell enhancer ABC_E727 Neighboring gene TBC1 domain family, member 10a Neighboring gene STARR-positive B cell enhancer ABC_E2978 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene predicted gene 11956

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in U2-type prespliceosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2 snRNP ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type prespliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
splicing factor 3A subunit 1
Names
SF3a120
splicing factor 3 subunit 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026175.5NP_080451.4  splicing factor 3A subunit 1

    See identical proteins and their annotated locations for NP_080451.4

    Status: VALIDATED

    Source sequence(s)
    AI115048, AK028829, AK030115, AK160061, AL807825
    Consensus CDS
    CCDS24380.1
    UniProtKB/Swiss-Prot
    Q8C0M7, Q8C128, Q8C175, Q8K4Z5, Q921T3
    UniProtKB/TrEMBL
    Q3TVM1
    Related
    ENSMUSP00000002198.4, ENSMUST00000002198.4
    Conserved Domains (4) summary
    cd01800
    Location:716791
    SF3a120_C; Ubiquitin-like domain of Mammalian splicing factor SF3a_120
    smart00648
    Location:50103
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam01805
    Location:165215
    Surp; Surp module
    pfam12230
    Location:232470
    PRP21_like_P; Pre-mRNA splicing factor PRP21 like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4110354..4132541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)