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SSR2 signal sequence receptor subunit 2 [ Homo sapiens (human) ]

Gene ID: 6746, updated on 18-Aug-2020

Summary

Official Symbol
SSR2provided by HGNC
Official Full Name
signal sequence receptor subunit 2provided by HGNC
Primary source
HGNC:HGNC:11324
See related
Ensembl:ENSG00000163479 MIM:600867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLAP; HSD25; TRAPB; TRAP-BETA
Summary
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 141.0), adrenal (RPKM 105.9) and 25 other tissues See more
Orthologs

Genomic context

See SSR2 in Genome Data Viewer
Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156009048..156020951, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155978839..155990758, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Rho/Rac guanine nucleotide exchange factor 2 Neighboring gene ARHGEF2 antisense RNA 2 Neighboring gene ARHGEF2 antisense RNA 1 Neighboring gene uncharacterized LOC107985208 Neighboring gene uncharacterized LOC105371729 Neighboring gene ubiquilin 4 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F19123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
translocon-associated protein subunit beta
Names
SSR-beta
signal sequence receptor subunit beta
signal sequence receptor, beta (translocon-associated protein beta)
translocon-associated protein beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003145.4NP_003136.1  translocon-associated protein subunit beta precursor

    See identical proteins and their annotated locations for NP_003136.1

    Status: REVIEWED

    Source sequence(s)
    AK222600, BP196192, X74104
    Consensus CDS
    CCDS1126.1
    UniProtKB/Swiss-Prot
    P43308
    Related
    ENSP00000295702.4, ENST00000295702.9
    Conserved Domains (1) summary
    pfam05753
    Location:4179
    TRAP_beta; Translocon-associated protein beta (TRAPB)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156009048..156020951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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