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SSB Sjogren syndrome antigen B [ Homo sapiens (human) ]

Gene ID: 6741, updated on 8-Jul-2018
Official Symbol
SSBprovided by HGNC
Official Full Name
Sjogren syndrome antigen Bprovided by HGNC
Primary source
HGNC:HGNC:11316
See related
Ensembl:ENSG00000138385 MIM:109090; Vega:OTTHUMG00000132212
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
La; LARP3; La/SSB
Summary
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in fat (RPKM 51.7), thyroid (RPKM 36.0) and 25 other tissues See more
Orthologs
See SSB in Genome Data Viewer
Location:
2q31.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (169798812..169812064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170655322..170668574)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene patched domain containing 3 pseudogene 2 Neighboring gene cytochrome b5 type A pseudogene 2 Neighboring gene methyltransferase like 5 Neighboring gene small nucleolar RNA, C/D box 3K Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene VISTA enhancer hs1867

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of Sjogren syndrome antigen B (SSB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with Sjogren syndrome antigen B ( SSB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
rev HIV-1 Rev interacting protein, Sjogren syndrome antigen B (SSB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SSB is increased by RRE PubMed
Tat tat The La autoantigen binds to HIV-1 TAR RNA and alleviates translational repression by the HIV-1 leader RNA, suggesting a possible involvement of the La autoantigen in HIV-1 gene expression and Tat transactivation PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of Sjogren syndrome antigen B (SSB, autoantigen La) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human Sjogren syndrome antigen B (SSB; autoantigen La) at amino acid residues 24-25 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA binding TAS
Traceable Author Statement
more info
PubMed 
poly(U) RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific mRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
histone mRNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
nuclear histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
tRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
tRNA 5'-leader removal IGI
Inferred from Genetic Interaction
more info
PubMed 
tRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA modification TAS
Traceable Author Statement
more info
PubMed 
tRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
lupus La protein
Names
La ribonucleoprotein domain family, member 3
SS-B
SS-B/La protein
autoantigen La
la autoantigen
lupus La antigen
sjoegren syndrome type B antigen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030640.1 RefSeqGene

    Range
    5001..18253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001294145.1NP_001281074.1  lupus La protein

    See identical proteins and their annotated locations for NP_001281074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AC009967, BC001289, X69804
    Consensus CDS
    CCDS2237.1
    UniProtKB/Swiss-Prot
    P05455
    Related
    ENSP00000386636.1, OTTHUMP00000204778, ENST00000409333.1, OTTHUMT00000333316
    Conserved Domains (3) summary
    cd08028
    Location:1091
    LARP_3; La RNA-binding domain of La-related protein 3
    cd12291
    Location:112183
    RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
    pfam08777
    Location:231334
    RRM_3; RNA binding motif
  2. NM_003142.4NP_003133.1  lupus La protein

    See identical proteins and their annotated locations for NP_003133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    BC001289, CD676196
    Consensus CDS
    CCDS2237.1
    UniProtKB/Swiss-Prot
    P05455
    Related
    ENSP00000260956.4, OTTHUMP00000163067, ENST00000260956.8, OTTHUMT00000255270
    Conserved Domains (3) summary
    cd08028
    Location:1091
    LARP_3; La RNA-binding domain of La-related protein 3
    cd12291
    Location:112183
    RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
    pfam08777
    Location:231334
    RRM_3; RNA binding motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    169798812..169812064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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