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C1qtnf12 C1q and tumor necrosis factor related 12 [ Mus musculus (house mouse) ]

Gene ID: 67389, updated on 18-Sep-2024

Summary

Official Symbol
C1qtnf12provided by MGI
Official Full Name
C1q and tumor necrosis factor related 12provided by MGI
Primary source
MGI:MGI:1914639
See related
Ensembl:ENSMUSG00000023571 AllianceGenome:MGI:1914639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C1qdc2; CTRP12; Fam132a; alipolin; 1110035L05Rik
Summary
Enables hormone activity. Involved in regulation of glucose import. Acts upstream of or within several processes, including negative regulation of gluconeogenesis; positive regulation of cell communication; and positive regulation of glucose import. Located in extracellular space. Is expressed in cochlea; genitourinary system; liver lobe; thyroid gland; and vibrissa. Orthologous to human C1QTNF12 (C1q and TNF related 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 84.1), adrenal adult (RPKM 49.9) and 23 other tissues See more
Orthologs
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Genomic context

See C1qtnf12 in Genome Data Viewer
Location:
4 E2; 4 87.66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156046769..156051086)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155962312..155966629)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sodium channel, nonvoltage-gated 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E10298 Neighboring gene STARR-seq mESC enhancer starr_12277 Neighboring gene ubiquitin-conjugating enzyme E2J 2 Neighboring gene STARR-seq mESC enhancer starr_12278 Neighboring gene predicted gene, 42365 Neighboring gene STARR-seq mESC enhancer starr_12279 Neighboring gene UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 Neighboring gene stromal cell derived factor 4 Neighboring gene tumor necrosis factor receptor superfamily, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of D-glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of D-glucose import IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of D-glucose import IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adipolin
Names
C1q domain containing 2
adipose-derived insulin-sensitizing factor
complement C1q tumor necrosis factor-related protein 12
family with sequence similarity 132, member A
protein FAM132A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026125.3NP_080401.1  adipolin precursor

    See identical proteins and their annotated locations for NP_080401.1

    Status: VALIDATED

    Source sequence(s)
    AK004116, AL627204, CO043709
    Consensus CDS
    CCDS19052.1
    UniProtKB/Swiss-Prot
    Q8R2Z0, Q9CQI8
    Related
    ENSMUSP00000024338.5, ENSMUST00000024338.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156046769..156051086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)