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Paxbp1 PAX3 and PAX7 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67367, updated on 12-Apr-2023

Summary

Official Symbol
Paxbp1provided by MGI
Official Full Name
PAX3 and PAX7 binding protein 1provided by MGI
Primary source
MGI:MGI:1914617
See related
Ensembl:ENSMUSG00000022974 AllianceGenome:MGI:1914617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcfc; Gcfc1; C21orf66; Pax3/7bp; 1810007M14Rik
Summary
Predicted to enable DNA binding activity. Acts upstream of or within positive regulation of myoblast proliferation; positive regulation of nitrogen compound metabolic process; and regulation of skeletal muscle satellite cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAXBP1 (PAX3 and PAX7 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 28.4), CNS E14 (RPKM 26.4) and 25 other tissues See more
Orthologs
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Genomic context

See Paxbp1 in Genome Data Viewer
Location:
16; 16 C3.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90810925..90841267, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91014037..91044379, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:90935026-90935209 Neighboring gene cilia and flagella associate protien 298 Neighboring gene synaptojanin 1 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene RIKEN cDNA 4932438H23 gene Neighboring gene H3.3 histone A, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
PAX3- and PAX7-binding protein 1
Names
GC-rich sequence DNA-binding factor 1
GC-rich sequence DNA-binding factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026110.2NP_080386.3  PAX3- and PAX7-binding protein 1

    See identical proteins and their annotated locations for NP_080386.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC141885
    Consensus CDS
    CCDS49908.1
    UniProtKB/Swiss-Prot
    P58501, Q9CRB7
    Related
    ENSMUSP00000113835.2, ENSMUST00000118522.8
    Conserved Domains (1) summary
    pfam07842
    Location:597808
    GCFC; GC-rich sequence DNA-binding factor-like protein

RNA

  1. NR_152264.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC141885

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    90810925..90841267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)