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Mrpl46 mitochondrial ribosomal protein L46 [ Mus musculus (house mouse) ]

Gene ID: 67308, updated on 8-Dec-2022

Summary

Official Symbol
Mrpl46provided by MGI
Official Full Name
mitochondrial ribosomal protein L46provided by MGI
Primary source
MGI:MGI:1914558
See related
Ensembl:ENSMUSG00000030612 AllianceGenome:MGI:1914558
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIECG2; P2ECSL; C15orf4; 3110052F15Rik
Summary
Predicted to be a structural constituent of ribosome. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL46 (mitochondrial ribosomal protein L46). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 18.5), liver E14 (RPKM 16.4) and 28 other tissues See more
Orthologs
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Genomic context

See Mrpl46 in Genome Data Viewer
Location:
7; 7 D2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78425089..78432837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (78775341..78783089, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E430016F16 gene Neighboring gene predicted gene, 30892 Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene de-etiolated homolog 1 (Arabidopsis)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
39S ribosomal protein L46, mitochondrial
Names
L46mt
MRP-L46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023331.2NP_075820.1  39S ribosomal protein L46, mitochondrial

    See identical proteins and their annotated locations for NP_075820.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061094
    Consensus CDS
    CCDS21373.1
    UniProtKB/Swiss-Prot
    Q9EQI8
    Related
    ENSMUSP00000032841.6, ENSMUST00000032841.7
    Conserved Domains (2) summary
    cd04661
    Location:142273
    MRP_L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the Nudix hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. ...
    pfam11788
    Location:47139
    MRP-L46; 39S mitochondrial ribosomal protein L46

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    78425089..78432837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)