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Pbld2 phenazine biosynthesis-like protein domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 67307, updated on 26-Sep-2022

Summary

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Official Symbol
Pbld2provided by MGI
Official Full Name
phenazine biosynthesis-like protein domain containing 2provided by MGI
Primary source
MGI:MGI:1914557
See related
Ensembl:ENSMUSG00000020072 AllianceGenome:MGI:1914557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mawbp; 3110049J23Rik
Summary
Predicted to enable identical protein binding activity and isomerase activity. Predicted to be involved in maintenance of gastrointestinal epithelium; negative regulation of SMAD protein signal transduction; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in pancreas epithelium and renal calyx. Orthologous to human PBLD (phenazine biosynthesis like protein domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 25.9), large intestine adult (RPKM 8.4) and 6 other tissues See more
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Genomic context

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See Pbld2 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62856086..62894592)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63024053..63058813)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1 Neighboring gene atonal bHLH transcription factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of gastrointestinal epithelium ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phenazine biosynthesis-like domain-containing protein 2
Names
MAWD binding protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405744.1 → NP_001392673.1  phenazine biosynthesis-like domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC113107
    UniProtKB/Swiss-Prot
    Q9D2W4

  2. NM_001405745.1 → NP_001392674.1  phenazine biosynthesis-like domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC113107
    UniProtKB/Swiss-Prot
    Q9D2W4

  3. NM_001405746.1 → NP_001392675.1  phenazine biosynthesis-like domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC113107
    UniProtKB/Swiss-Prot
    Q9D2W4

  4. NM_026085.3 → NP_080361.1  phenazine biosynthesis-like domain-containing protein 2

    See identical proteins and their annotated locations for NP_080361.1

    Status: VALIDATED

    Source sequence(s)
    AC113107
    Consensus CDS
    CCDS23894.1
    UniProtKB/Swiss-Prot
    Q9CXN7, Q9D2W4
    Related
    ENSMUSP00000020262.5, ENSMUST00000020262.5
    Conserved Domains (1) summary
    cl29427
    Location:9 → 284
    PhzC-PhzF; Phenazine biosynthesis-like protein

RNA

  1. NR_175965.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113107

  2. NR_175966.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113107

  3. NR_175967.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113107

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62856086..62894592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155961.1 → XP_036011854.1  phenazine biosynthesis-like domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cl29427
    Location:9 → 284
    PhzC-PhzF; Phenazine biosynthesis-like protein

  2. XM_006513981.4 → XP_006514044.1  phenazine biosynthesis-like domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514044.1

    Conserved Domains (1) summary
    cl29427
    Location:70 → 345
    PhzC-PhzF; Phenazine biosynthesis-like protein

  3. XM_006513982.5 → XP_006514045.1  phenazine biosynthesis-like domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    cl29427
    Location:63 → 338
    PhzC-PhzF; Phenazine biosynthesis-like protein

  4. XM_006513983.2 → XP_006514046.1  phenazine biosynthesis-like domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl29427
    Location:46 → 321
    PhzC-PhzF; Phenazine biosynthesis-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXN7.1 GenPept UniProtKB/Swiss-Prot:Q9CXN7

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