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Rab3c RAB3C, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 67295, updated on 8-Dec-2022

Summary

Official Symbol
Rab3cprovided by MGI
Official Full Name
RAB3C, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1914545
See related
Ensembl:ENSMUSG00000021700 AllianceGenome:MGI:1914545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700062I01Rik; 3110015B08Rik; 3110037E15Rik
Summary
Enables GTP-dependent protein binding activity. Acts upstream of or within regulation of exocytosis. Located in synaptic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; sensory organ; and skeleton. Orthologous to human RAB3C (RAB3C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 16.0), frontal lobe adult (RPKM 15.2) and 5 other tissues See more
Orthologs
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Genomic context

See Rab3c in Genome Data Viewer
Location:
13; 13 D2.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (110190721..110417530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (110054187..110280996, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D, cAMP specific Neighboring gene microRNA 1904 Neighboring gene predicted gene, 32881 Neighboring gene predicted gene, 53813 Neighboring gene predicted gene, 41057 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene Grb2-binding adaptor, transmembrane

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124069

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin V binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-3C
Names
small GTP-binding protein Rab3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360099.1NP_001347028.1  ras-related protein Rab-3C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124235, AC154470, CT025643
    Consensus CDS
    CCDS88528.1
    UniProtKB/TrEMBL
    A0A286YDR2
    Related
    ENSMUSP00000153347.2, ENSMUST00000223922.2
    Conserved Domains (1) summary
    cd01865
    Location:28192
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
  2. NM_023852.5NP_076341.1  ras-related protein Rab-3C isoform 1

    See identical proteins and their annotated locations for NP_076341.1

    Status: VALIDATED

    Source sequence(s)
    AK164316, CJ123980, CT025643
    Consensus CDS
    CCDS26764.1
    UniProtKB/Swiss-Prot
    P62823, Q9CXQ1
    UniProtKB/TrEMBL
    A0A6P5QXA9, Q542T7
    Related
    ENSMUSP00000132945.2, ENSMUST00000167824.3
    Conserved Domains (1) summary
    cd01865
    Location:30194
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    110190721..110417530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517741.4XP_006517804.1  ras-related protein Rab-3C isoform X1

    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
  2. XM_006517742.5XP_006517805.1  ras-related protein Rab-3C isoform X2

    See identical proteins and their annotated locations for XP_006517805.1

    UniProtKB/TrEMBL
    A0A6P5QZT0, Q9CXS2
    Related
    ENSMUSP00000153136.2, ENSMUST00000224180.2
    Conserved Domains (1) summary
    cl38936
    Location:30166
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases