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SRP54 signal recognition particle 54 [ Homo sapiens (human) ]

Gene ID: 6729, updated on 21-Jun-2021

Summary

Official Symbol
SRP54provided by HGNC
Official Full Name
signal recognition particle 54provided by HGNC
Primary source
HGNC:HGNC:11301
See related
Ensembl:ENSG00000100883 MIM:604857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCN8
Expression
Ubiquitous expression in testis (RPKM 26.2), thyroid (RPKM 18.4) and 25 other tissues See more
Orthologs
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Genomic context

See SRP54 in Genome Data Viewer
Location:
14q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (34982981..35029567)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35452198..35498773)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 1A Neighboring gene BAZ1A antisense RNA 1 Neighboring gene SRP54 antisense RNA 1 Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 1 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene protein only RNase P catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, signal recognition particle 54kDa (SRP54), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 7S RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA binding HDA PubMed 
enables endoplasmic reticulum signal peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endoplasmic reticulum signal peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal recognition particle 54 kDa protein
Names
signal recognition particle 54kD
signal recognition particle 54kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146282.2NP_001139754.1  signal recognition particle 54 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_001139754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and uses a distinct translational start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK300824, BC000652, DA495064
    UniProtKB/Swiss-Prot
    P61011
    Related
    ENSP00000451775.1, ENST00000555557.5
    Conserved Domains (1) summary
    TIGR01425
    Location:8381
    SRP54_euk; signal recognition particle protein SRP54
  2. NM_003136.4NP_003127.1  signal recognition particle 54 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC000652, DA495064
    Consensus CDS
    CCDS9652.1
    UniProtKB/Swiss-Prot
    P61011
    Related
    ENSP00000216774.6, ENST00000216774.11
    Conserved Domains (1) summary
    TIGR01425
    Location:2430
    SRP54_euk; signal recognition particle protein SRP54

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    34982981..35029567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268024.3XP_005268081.1  signal recognition particle 54 kDa protein isoform X2

    Related
    ENSP00000451647.2, ENST00000555746.6
    Conserved Domains (1) summary
    TIGR01425
    Location:2385
    SRP54_euk; signal recognition particle protein SRP54
  2. XM_017021615.2XP_016877104.1  signal recognition particle 54 kDa protein isoform X3

    Conserved Domains (1) summary
    TIGR01425
    Location:1326
    SRP54_euk; signal recognition particle protein SRP54
  3. XM_011537106.1XP_011535408.1  signal recognition particle 54 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_011535408.1

    UniProtKB/Swiss-Prot
    P61011
    Related
    ENSP00000504673.1, ENST00000677647.1
    Conserved Domains (1) summary
    TIGR01425
    Location:2430
    SRP54_euk; signal recognition particle protein SRP54
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