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SRP54 signal recognition particle 54 [ Homo sapiens (human) ]

Gene ID: 6729, updated on 1-Jun-2020

Summary

Official Symbol
SRP54provided by HGNC
Official Full Name
signal recognition particle 54provided by HGNC
Primary source
HGNC:HGNC:11301
See related
Ensembl:ENSG00000100883 MIM:604857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCN8
Expression
Ubiquitous expression in testis (RPKM 26.2), thyroid (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See SRP54 in Genome Data Viewer
Location:
14q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (34982898..35029567)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35451901..35498773)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 1A Neighboring gene uncharacterized LOC112268124 Neighboring gene SRP54 antisense RNA 1 (head to head) Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 1 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene protein only RNase P catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, signal recognition particle 54kDa (SRP54), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7S RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum signal peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum signal peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal recognition particle 54 kDa protein
Names
signal recognition particle 54kD
signal recognition particle 54kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146282.1NP_001139754.1  signal recognition particle 54 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_001139754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and uses a distinct translational start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK300824, BC000652, DA495064
    Consensus CDS
    CCDS53893.1
    UniProtKB/Swiss-Prot
    P61011
    Related
    ENSP00000440629.1, ENST00000546080.5
    Conserved Domains (1) summary
    TIGR01425
    Location:8381
    SRP54_euk; signal recognition particle protein SRP54
  2. NM_003136.4NP_003127.1  signal recognition particle 54 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC000652, DA495064
    Consensus CDS
    CCDS9652.1
    UniProtKB/Swiss-Prot
    P61011
    Related
    ENSP00000216774.6, ENST00000216774.11
    Conserved Domains (1) summary
    TIGR01425
    Location:2430
    SRP54_euk; signal recognition particle protein SRP54

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    34982898..35029567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268024.3XP_005268081.1  signal recognition particle 54 kDa protein isoform X2

    Conserved Domains (1) summary
    cl27330
    Location:2385
    FlhF; Flagellar biosynthesis GTPase FlhF [Cell motility]
  2. XM_017021615.2XP_016877104.1  signal recognition particle 54 kDa protein isoform X3

    Conserved Domains (2) summary
    pfam00448
    Location:1190
    SRP54; SRP54-type protein, GTPase domain
    pfam02978
    Location:222325
    SRP_SPB; Signal peptide binding domain
  3. XM_011537106.1XP_011535408.1  signal recognition particle 54 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_011535408.1

    UniProtKB/Swiss-Prot
    P61011
    Conserved Domains (1) summary
    TIGR01425
    Location:2430
    SRP54_euk; signal recognition particle protein SRP54
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