Eri1 exoribonuclease 1 [Mus musculus (house mouse)] -

Summary

Official Symbol: Eri1provided by MGI
Official Full Name: exoribonuclease 1provided by MGI
Primary source: MGI:MGI:1914526
See related: Ensembl:ENSMUSG00000031527 AllianceGenome:MGI:1914526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thex1; eri-1; 3'hexo; 3110010F15Rik
Summary: Enables histone pre-mRNA stem-loop binding activity; rRNA binding activity; and ribosome binding activity. Involved in rRNA 3'-end processing. Located in cytoplasm and nucleolus. Part of histone pre-mRNA 3'end processing complex. Is expressed in early conceptus; eye; inner cell mass; limb; and oocyte. Orthologous to human ERI1 (exoribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 5.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 A4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (35932419..35962687, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (35465265..35495533, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

7SB ribosomal RNA can be oligoadenylated by an unknown enzyme and/or oligouridylated by TUT4/7 and subsequently processed by Dis3l2 and Eri1.
Title: Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance.
data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure
Title: Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity.
Title: Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
The roles of meri-1 (mouse enhanced RNAi) and adar1 in the regulation of RNA interference are reported.
Title: High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse.
Findings indicate that Eri1 catalyzes the final trimming step in 5.8S rRNA processing, functionally and spatially connecting this regulator of RNAi with the basal translation machinery.
Title: Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Eri1 gene: The Eri1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, C.elegans, S.pombe, and frog.
Orthologs from Annotation Pipeline: 490 organisms have orthologs with human gene Eri1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables histone pre-mRNA stem-loop binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in rRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of histone pre-mRNA 3'end processing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3'-5' exoribonuclease 1

Names: 3'-5' exonuclease ERI1; enhanced RNAi protein 1; eri-1 homolog; histone mRNA 3' end-specific exonuclease; histone mRNA 3'-exonuclease 1; three prime histone mRNA exonuclease 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026067.3 → NP_080343.4 3'-5' exoribonuclease 1

See identical proteins and their annotated locations for NP_080343.4

Status: VALIDATED

Source sequence(s)

AK014410, AK050230, AK161031, AK165026

Consensus CDS

CCDS22244.1

UniProtKB/Swiss-Prot

Q7TMF2

UniProtKB/TrEMBL

A0A0R4J0C8, Q8BV98

Related

ENSMUSP00000033927.7, ENSMUST00000033927.8

Conserved Domains (2) summary

cd06133
Location:126 → 306

ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

pfam02037
Location:72 → 106

SAP; SAP domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

35932419..35962687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154250.1 → XP_036010143.1 3'-5' exoribonuclease 1 isoform X1

Conserved Domains (2) summary

cd06133
Location:60 → 240

ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

pfam02037
Location:6 → 40

SAP; SAP domain