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SRP14 signal recognition particle 14 [ Homo sapiens (human) ]

Gene ID: 6727, updated on 5-Jul-2020

Summary

Official Symbol
SRP14provided by HGNC
Official Full Name
signal recognition particle 14provided by HGNC
Primary source
HGNC:HGNC:11299
See related
Ensembl:ENSG00000140319 MIM:600708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALURBP
Expression
Ubiquitous expression in endometrium (RPKM 125.3), adrenal (RPKM 118.3) and 25 other tissues See more
Orthologs

Genomic context

See SRP14 in Genome Data Viewer
Location:
15q15.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40035690..40039202, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40327891..40331389, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene H3 histone pseudogene 38 Neighboring gene Sharpr-MPRA regulatory region 10520 Neighboring gene SRP14 antisense RNA1 (head to head) Neighboring gene uncharacterized LOC105370787

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with signal recognition particle 14kDa (SRP14, homologous Alu RNA binding protein) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of signal recognition particle 14kDa (SRP14) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
endoplasmic reticulum signal peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal recognition particle 14 kDa protein
Names
18 kDa Alu RNA-binding protein
homologous Alu RNA binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309434.1NP_001296363.1  signal recognition particle 14 kDa protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in its 5' coding region, which results in a frameshift and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to variant 1.
    Source sequence(s)
    AC025168, BC051006, DA338824
    Conserved Domains (1) summary
    pfam02290
    Location:2346
    SRP14; Signal recognition particle 14kD protein
  2. NM_003134.6NP_003125.3  signal recognition particle 14 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003125.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC035495, CV575824, DA338824
    Consensus CDS
    CCDS42017.1
    UniProtKB/Swiss-Prot
    P37108
    Related
    ENSP00000267884.6, ENST00000267884.11
    Conserved Domains (1) summary
    pfam02290
    Location:494
    SRP14; Signal recognition particle 14kD protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    40035690..40039202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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