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Myl12a myosin, light chain 12A, regulatory, non-sarcomeric [ Mus musculus (house mouse) ]

Gene ID: 67268, updated on 24-Sep-2025
Official Symbol
Myl12aprovided by MGI
Official Full Name
myosin, light chain 12A, regulatory, non-sarcomericprovided by MGI
Primary source
MGI:MGI:1914518
See related
Ensembl:ENSMUSG00000024048 AllianceGenome:MGI:1914518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900073G15Rik
Summary
Enables glutamate receptor binding activity. Acts upstream of or within protein localization to plasma membrane and regulation of cell shape. Located in Z disc and stress fiber. Part of myosin II complex. Orthologous to human MYL12A (myosin light chain 12A). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 191.4), heart adult (RPKM 159.8) and 28 other tissues See more
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Location:
17 E1.3; 17 41.87 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71300788..71309528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (70993793..71002533, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46595 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71323576-71323876 Neighboring gene predicted gene, 41611 Neighboring gene STARR-seq mESC enhancer starr_43170 Neighboring gene myosin, light chain 12B, regulatory Neighboring gene STARR-positive B cell enhancer ABC_E3214 Neighboring gene predicted gene, 53974 Neighboring gene myomesin 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Novel insights into palatal shelf elevation dynamics in normal mouse embryos. Goering JP, et al. Front Cell Dev Biol, 2025. PMID 40008102, Free PMC Article
  2. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. Höpker K, et al. EMBO J, 2012 Oct 17. PMID 22909821, Free PMC Article
  3. N-methyl-D-aspartate receptor subunits are non-myosin targets of myosin regulatory light chain. Bajaj G, et al. J Biol Chem, 2009 Jan 9. PMID 18945678, Free PMC Article
  4. Stage-dependent function of Wnt5a during male external genitalia development. Alcantara MC, et al. Congenit Anom (Kyoto), 2021 Nov. PMID 34255394
  5. Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Sun J, et al. Front Physiol, 2020. PMID 33424621, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
myosin light chain, regulatory B-like
Names
NMDA receptor-interacting protein
brain specific myosin regulatory light chain

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357820.1 → NP_001344749.1  myosin light chain, regulatory B-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154187, AI838292, BF661452, DV063953
    UniProtKB/TrEMBL
    Q9D6E6
    Conserved Domains (1) summary
    COG5126
    Location:25 → 175
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_026064.2 → NP_080340.2  myosin light chain, regulatory B-like isoform 1

    See identical proteins and their annotated locations for NP_080340.2

    Status: VALIDATED

    Source sequence(s)
    AK045160, BY258797, BY319676, CAAA01075437
    Consensus CDS
    CCDS28955.1
    UniProtKB/TrEMBL
    Q6ZWQ9, Q9D6E6
    Related
    ENSMUSP00000123412.2, ENSMUST00000148960.8
    Conserved Domains (1) summary
    COG5126
    Location:19 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71300788..71309528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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