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SRP9 signal recognition particle 9 [ Homo sapiens (human) ]

Gene ID: 6726, updated on 21-Dec-2019

Summary

Official Symbol
SRP9provided by HGNC
Official Full Name
signal recognition particle 9provided by HGNC
Primary source
HGNC:HGNC:11304
See related
Ensembl:ENSG00000143742 MIM:600707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALURBP
Expression
Ubiquitous expression in adrenal (RPKM 131.7), brain (RPKM 102.1) and 25 other tissues See more
Orthologs

Genomic context

See SRP9 in Genome Data Viewer
Location:
1q42.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (225777813..225790466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225965515..225978168)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985352 Neighboring gene RNA, U6 small nuclear 1304, pseudogene Neighboring gene VISTA enhancer hs2374 Neighboring gene left-right determination factor 2 pseudogene Neighboring gene epoxide hydrolase 1 Neighboring gene transmembrane protein 63A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
Rev rev HIV-1 Rev interacting protein, signal recognition particle 9kDa (SRP9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SRP9 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal recognition particle binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
negative regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
signal recognition particle receptor complex TAS
Traceable Author Statement
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
signal recognition particle 9 kDa protein
Names
signal recognition particle 9kD
signal recognition particle 9kDa
NP_001123912.1
NP_003124.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130440.1NP_001123912.1  signal recognition particle 9 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_001123912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    BC021995, DA983529, EF488978
    Consensus CDS
    CCDS44323.1
    UniProtKB/Swiss-Prot
    P49458
    UniProtKB/TrEMBL
    A0A024R3P3
    Related
    ENSP00000355804.4, ENST00000366839.8
    Conserved Domains (1) summary
    pfam05486
    Location:451
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)
  2. NM_003133.5NP_003124.1  signal recognition particle 9 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_003124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC008443, BC021995, DA983529
    Consensus CDS
    CCDS1546.1
    UniProtKB/Swiss-Prot
    P49458
    Related
    ENSP00000305230.7, ENST00000304786.11
    Conserved Domains (1) summary
    pfam05486
    Location:473
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    225777813..225790466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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