U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnf213 ring finger protein 213 [ Mus musculus (house mouse) ]

Gene ID: 672511, updated on 12-May-2024

Summary

Official Symbol
Rnf213provided by MGI
Official Full Name
ring finger protein 213provided by MGI
Primary source
MGI:MGI:1289196
See related
Ensembl:ENSMUSG00000070327 AllianceGenome:MGI:1289196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mysterin; 6030403J01; D11Ertd759e
Summary
Predicted to enable ubiquitin-protein transferase activity. Involved in angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleolus. Is expressed in hindgut; metanephros; pericardial component; testis; and thymus primordium. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 12.0), thymus adult (RPKM 11.4) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rnf213 in Genome Data Viewer
Location:
11 E2; 11 83.48 cM
Exon count:
70
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119280778..119378245)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119389950..119487418)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 14 Neighboring gene solute carrier family 26, member 11 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene STARR-seq mESC enhancer starr_31317 Neighboring gene microRNA 1932 Neighboring gene STARR-positive B cell enhancer ABC_E3043 Neighboring gene RIKEN cDNA A930037H05 gene Neighboring gene STARR-positive B cell enhancer ABC_E7112 Neighboring gene endonuclease V Neighboring gene STARR-positive B cell enhancer ABC_E8475 Neighboring gene predicted gene, 39484

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1554

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF213
Names
E3 ubiquitin-lipopolysaccharide ligase RNF213
RING-type E3 ubiquitin transferase RNF213
NP_001035094.2
XP_006534693.1
XP_006534694.1
XP_006534695.1
XP_006534696.1
XP_030102102.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040005.3NP_001035094.2  E3 ubiquitin-protein ligase RNF213

    Status: VALIDATED

    Source sequence(s)
    AL645911
    UniProtKB/Swiss-Prot
    E9Q555, F7A6H4, Q8BVK6
    UniProtKB/TrEMBL
    A0A8I4P9C4
    Related
    ENSMUSP00000091429.6, ENSMUST00000093902.12
    Conserved Domains (5) summary
    smart00382
    Location:23742501
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:38783985
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:39473985
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:326
    DZR; Double zinc ribbon
    cl17238
    Location:39473986
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119280778..119378245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534633.5XP_006534696.1  E3 ubiquitin-protein ligase RNF213 isoform X4

    See identical proteins and their annotated locations for XP_006534696.1

    UniProtKB/TrEMBL
    A0A8I4P9C4
    Conserved Domains (5) summary
    smart00382
    Location:24172544
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:39224029
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:39914029
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:326
    DZR; Double zinc ribbon
    cl17238
    Location:39914030
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_006534630.5XP_006534693.1  E3 ubiquitin-protein ligase RNF213 isoform X1

    See identical proteins and their annotated locations for XP_006534693.1

    UniProtKB/TrEMBL
    A0A8I4P9C4
    Conserved Domains (5) summary
    smart00382
    Location:24172544
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:39224029
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:39914029
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:326
    DZR; Double zinc ribbon
    cl17238
    Location:39914030
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. XM_006534631.5XP_006534694.1  E3 ubiquitin-protein ligase RNF213 isoform X2

    See identical proteins and their annotated locations for XP_006534694.1

    UniProtKB/TrEMBL
    A0A8I4P9C4
    Conserved Domains (5) summary
    smart00382
    Location:24172544
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:39214028
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:39904028
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:326
    DZR; Double zinc ribbon
    cl17238
    Location:39904029
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  4. XM_006534632.5XP_006534695.1  E3 ubiquitin-protein ligase RNF213 isoform X3

    See identical proteins and their annotated locations for XP_006534695.1

    UniProtKB/TrEMBL
    A0A8I4P9C4
    Conserved Domains (5) summary
    smart00382
    Location:23742501
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:38793986
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:39483986
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:326
    DZR; Double zinc ribbon
    cl17238
    Location:39483987
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  5. XM_030246242.2XP_030102102.1  E3 ubiquitin-protein ligase RNF213 isoform X1

    UniProtKB/TrEMBL
    A0A8I4P9C4
    Conserved Domains (5) summary
    smart00382
    Location:24172544
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:39224029
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:39914029
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:326
    DZR; Double zinc ribbon
    cl17238
    Location:39914030
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain